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The Journal of Immunology

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List of all Pillars of Immunology articles

From the Current Issue:  November 1 2020; 205 (9) [Table of Contents]

There are no new Pillars of Immunology articles in this issue.

From Past Issues:

Glial Cells as Regulators of Neuroimmune Interactions in the Central Nervous System

Jack P. Antel, Burkhard Becher, Samuel K. Ludwin, Alexandre Prat and Francisco J. Quintana
J Immunol 2020 204: 251-255


The Colon as a Major Site of Immunoregulation by CD4+ T Cell Subsets in the Steady State

Alan Sher and Brian L. Kelsall
J Immunol 2019 203: 1683-1684


Assembling the Inflammasome, Piece by Piece

Fiachra Humphries and Katherine A. Fitzgerald
J Immunol 2019 203: 1093-1094 | ImmunoCast


Complement in Motion: The Evolution of CD46 from a Complement Regulator to an Orchestrator of Normal Cell Physiology

M. Kathryn Liszewski and Claudia Kemper
J Immunol 2019 203: 3-5 | ImmunoCast


Mystery Solved: IL-15

Todd A. Fehniger
J Immunol 2019 202: 3125-3126 | ImmunoCast


Unmasking the Mysteries of MYC

Rajeev M. Nepal and Alberto Martini
J Immunol 2019 202: 2517-2518 | ImmunoCast


On the Road to Discovering the Elusive Executioner of Pyroptosis

David E. Place and Thirumala-Devi Kanneganti
J Immunol 2019 202: 1911-1912

Pillars Article: Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol. 2006. 8: 1812–1825

Susan L. Fink and Brad T. Cookson
J Immunol 2019 202:  1913-1926


From RAG2 to T Cell Riches and Future Fortunes

Rebecca A. Glynn and Craig H. Bassing
J Immunol 2019 202: 1315-1316 | ImmunoCast

Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825

Yoichi Shinkai, Shigeo Koyasu, Kei-ichi Nakayama, Kenneth M. Murphy, Dennis Y. Loh, Ellis L. Reinherz and Frederick W. Alt
J Immunol 2019 202:  1317-1320


The Tale of IL-12 and IL-23: A Paradigm Shift

Shabaana A. Khader and Shyamala Thirunavukkarasu
J Immunol 2019 202: 629-630 | ImmunoCast


Attracting Attention: Discovery of IL-8/CXCL8 and the Birth of the Chemokine Field

Bethany B. Moore and Steven L. Kunkel
J Immunol 2019 202: 3-4 | ImmunoCast

Pillars Article: Purification of a Human Monocyte-Derived Neutrophil Chemotactic Factor That Has Peptide Sequence Similarity to Other Host Defense Cytokines. Proc. Natl. Acad. Sci. USA 1987. 84: 9233–9237

Teizo Yoshimura, Kouji Matsushima, Shuji Tanaka, Elizabeth A. Robinson, Ettore Appella, Joost J. Oppenheim and Edward J. Leonard
J Immunol 2019 202:  5-9


Opening the Black Box of Immunosuppression

Mark H. Kaplan
J Immunol 2018 201: 3147-3148 | ImmunoCast

Pillars Article: Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation. Science. 1989. 246: 1617–1620

Elizabeth A. Emmel, Cornelis L. Verweij, David B. Durand, Kay M. Higgins, Elizabeth Lacy and Gerald R. Crabtree
J Immunol 2018 201:  3149-3152


The Common Key to Class-Switch Recombination and Somatic Hypermutation: Discovery of AID and Its Role in Antibody Gene Diversification

Rebecca J. Leeman-Neill, Junghyun Lim and Uttiya Basu
J Immunol 2018 201: 2527-2529 | ImmunoCast

Pillars Article: Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme. Cell. 2000. 102: 553–563

Masamichi Muramatsu, Kazuo Kinoshita, Sidonia Fagarasan, Shuichi Yamada, Yoichi Shinkai and Tasuku Honjo
J Immunol 2018 201:  2530-2540


How Superantigens Bind MHC

Luc Van Kaer
J Immunol 2018 201: 1817-1818 | ImmunoCast

Pillars Article: Three-Dimensional Structure of a Human Class II Histocompatibility Molecule Complexed with Superantigen. Nature. 1994. 368: 711–718

Theodore S. Jardetzky, Jerry H. Brown, Joan C. Gorga, Lawrence J. Stern, Robert G. Urban, Young-in Chi, Cynthia Stauffacher, Jack L. Strominger and Don C. Wiley
J Immunol 2018 201: 1819-1826


A Convergent Immunological Holy Trinity of Adaptive Immunity in Lampreys: Discovery of the Variable Lymphocyte Receptors

Martin F. Flajnik
J Immunol 2018 201: 1331-1335 | ImmunoCast

Pillars Article: Somatic Diversification of Variable Lymphocyte Receptors in the Agnathan Sea Lamprey. Nature. 2004. 430: 174–180

Zeev Pancer, Chris T. Amemiya, Götz R. A. Ehrhardt, Jill Ceitlin, G. Larry Gartland and Max D. Cooper
J Immunol 2018 201: 1336-1342


From Cancer Immune Surveillance to Cancer Immunoediting: Birth of Modern Immuno-Oncology

Wolf H. Fridman
J Immunol 2018 201: 825-826 | ImmunoCast

Pillars Article: IFNγ and Lymphocytes Prevent Primary Tumour Development and Shape Tumour Immunogenicity. Nature. 2001. 410: 1107–1111

Vijay Shankaran, Hiroaki Ikeda, Allen T. Bruce, J. Michael White, Paul E. Swanson, Lloyd J. Old and Robert D. Schreiber
J Immunol 2018 201: 827-831


Where Have All the Flowers Gone?

Philippa Marrack
J Immunol 2018 201: 5-6 | ImmunoCast

Pillars Article: T-Cell Apoptosis Detected In Situ during Positive and Negative Selection in the Thymus. Nature. 1994. 372: 100–103

Charles D. Surh and Jonathan Sprent
J Immunol 2018 201: 7-10


Discovering the Cause of Wiskott–Aldrich Syndrome and Laying the Foundation for Understanding Immune Cell Structuring

Emily M. Mace and Jordan S. Orange
J Immunol 2018 200: 3667-3670 | ImmunoCast

Pillars Article: Isolation of a Novel Gene Mutated in Wiskott-Aldrich Syndrome. Cell. 1994. 78: 635–644

Jonathan M. J. Derry, Hans D. Ochs and Uta Francke
J Immunol 2018 200: 3671-3680


Specialized Antitumor Functions for Skin γδ T Cells

Wendy L. Havran
J Immunol 2018 200: 2229-2230 | ImmunoCast

Pillars Article: Regulation of Cutaneous Malignancy by γδ T Cells. Science. 2001. 294: 605–609

Michael Girardi, David E. Oppenheim, Carrie R. Steele, Julia M. Lewis, Earl Glusac, Renata Filler, Paul Hobby, Brian Sutton, Robert E. Tigelaar and Adrian C. Hayday
J Immunol 2018 200: 3031-3035


NKG2D–MICA Interaction: A Paradigm Shift in Innate Recognition

Mathieu Bléry and Eric Vivier
J Immunol 2018 200: 2229-2230 | ImmunoCast

Pillars Article: Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science. 1999. 285: 727–729

Stefan Bauer, Veronika Groh, Jun Wu, Alexander Steinle, Joseph H. Phillips, Lewis L. Lanier and Thomas Spies
J Immunol 2018 200: 2231-2233


The Chemical Elucidation of Slow-Reacting Substance: Bronchospasm and Beyond

Marc Peters-Golden
J Immunol 2018 200: 1535-1537 | ImmunoCast

Pillars Article: Leukotriene C: A Slow-Reacting Substance from Murine Mastocytoma Cells. Proc. Natl. Acad. Sci. USA. 1979. 76: 4275–4279

Robert C. Murphy, Sven Hammarström and Bengt Samuelsson
J Immunol 2018 200: 1538-1542


Dendritic Cells on the Way to Glory

Sebastian Amigorena
J Immunol 2018 200: 885-886 | ImmunoCast

Pillars Article: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 1994. 179:1109–1118

Federica Sallusto and Antonio Lanzavecchia
J Immunol 2018 200: 887-896


The Reign of Antibodies: A Celebration of and Tribute to Michael Potter and His Homogeneous Immunoglobulin Workshops

Patricia J. Gearhart, Beverly A. Mock, Rafael Casellas and Michael P. Cancro
J Immunol 2018 200: 23-26 | ImmunoCast

Pillars Article: Evidence for Amino Acid Sequence Differences among Proteins Resembling the L-chain Subunits of Immunoglobulins. J. Mol. Biol. 1965. 12: 81–87

J. Claude Bennett, Leroy E. Hood, William J Dreyer and Michael Potter
J Immunol 2018 200: 27-37


Critical Functions of IRF4 in B and T Lymphocytes

James Hagman
J Immunol 2017 199: 3715-3716 | ImmunoCast

Pillars Article: Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function. Science. 1997. 275: 540–543

Hans-Willi Mittrücker, Toshifumi Matsuyama, Alex Grossman, Thomas M. Kündig, Julia Potter, Arda Shahinian, Andrew Wakeham, Bruce Patterson, Pamela S. Ohashi and Tak W. Mak
J Immunol 2017 199: 3717-3720


Stacking the Deck: Studies of Patients with Multiple Autoimmune Diseases Propelled Our Understanding of Type 1 Diabetes as an Autoimmune Disease

Jane H. Buckner and Carla J. Greenbaum
J Immunol 2017 199: 3011-3013 | ImmunoCast

Pillars Article: Islet-cell Antibodies in Diabetes Mellitus with Autoimmune Polyendocrine Deficiencies. Lancet. 1974. 304: 1279-1283

Gian Franco Bottazzo, Alejo Florin-Christensen and Deborah Doniach
J Immunol 2017 199: 3014-3018

Pillars Article: Antibodies to Pancreatic Islet Cells in Insulin-dependent Diabetics with Coexistent Autoimmune Disease. Lancet. 1974. 304: 1529-1531

A. C. MacCuish, W. J. Irvine, E. W. Barnes and L. J. P. Duncan
J Immunol 2017 199: 3019-3021


M1 Means Kill; M2 Means Heal

Klaus Ley
J Immunol 2017 199: 2191-2193 | ImmunoCast

Pillars Article: M-1/M-2 Macrophages and the Th1/Th2 Paradigm. J. Immunol. 2000. 164: 6166–6173

Charles D. Mills, Kristi Kincaid, Jennifer M. Alt, Michelle J. Heilman and Annette M. Hill
J Immunol 2017 199: 2194-2201


SAP and Lessons Learned from a Primary Immunodeficiency

Jennifer L. Cannons and Pamela L. Schwartzberg
J Immunol 2017 199: 1531-1533 | ImmunoCast

Pillars Article: The X-Linked Lymphoproliferative Disease Gene Product SAP Regulates Signals Induced through the Co-Receptor SLAM. Nature. 1998. 395: 462–469

J. Sayos, C. Wu, M. Morra, N. Wang, X. Zhang, D. Allen, S. van Schaik, L. Notarangelo, R. Geha, M. G. Roncarolo, H. Oettgen, J. E. De Vries, G. Aversa and C. Terhorst
J Immunol 2017 199: 1534-1541


Defining the Kinetics, Phenotype, and Function of T Cells Induced by Mycobacterium tuberculosis: Pillar of Immunity to Tuberculosis

Andrea M. Cooper
J Immunol 2017 199: 831-832 | ImmunoCast

Pillars Article: The Kinetics of Emergence and Loss of Mediator T Lymphocytes Acquired in Response to Infection with Mycobacterium Tuberculosis. J. Immunol. 1987. 138: 293–298

Ian M. Orme
J Immunol 2017 199: 833-838


Access Guide to Antigen Receptor Genes

Ranjan Sen
J Immunol 2017 199: 3-4 | ImmunoCast

Pillars Article: A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination. Science. 2000. 287: 495-498

Michelle Taylor McMurry and Michael S. Krangel
J Immunol 2017 199: 5-8


Monocyte-Derived Dendritic Cells: A Transendothelial Trip Launches the Quest To Understand Heterogeneity in the APC Family

Gabrielle T. Belz
J Immunol 2017 198: 4189-4190 | ImmunoCast

Pillars Article: Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking. Science. 1998. 282: 480–483

Gwendalyn J. Randolph, Sylvie Beaulieu, Serge Lebecque, Ralph M. Steinman and William A. Muller
J Immunol 2017 198: 4191-4194


T Cell–Transfer Experimental Autoimmune Encephalomyelitis: Pillar of Multiple Sclerosis and Autoimmunity

Reinhard Hohlfeld and Lawrence Steinman
J Immunol 2017 198: 3381-3383 | ImmunoCast

Pillars Article: The Rapid Isolation of Clonable Antigen-specific T Lymphocyte Lines Capable of Mediating Autoimmune Encephalomyelitis. Eur J Immunol. 1981.11: 195-199 Nature. 1984. 309: 763–767

Avraham Ben-Nun, Hartmut Wekerle and Irun R. Cohen
J Immunol 2017 198: 3384-3388


The Cloning of GM-CSF

Glenn Dranoff
J Immunol 2017 198: 2519-2521 | ImmunoCast

Pillars Article: Molecular Cloning of cDNA Encoding a Murine Haematopoietic Growth Regulator, Granulocyte—Macrophage Colony Stimulating Factor. Nature. 1984. 309: 763–767

Nicholas M. Gough, Jill Gough, Donald Metcalf, Anne Kelso, Dianne Grail, Nicos A. Nicola, Antony W. Burgess and Ashley R. Dunn
J Immunol 2017 198: 2522-2526


Two Cells, One Antibody: The Discovery of the Cellular Origins and Transport of Secretory IgA

Charlotte S. Kaetzel, Jiri Mestecky and Finn-Eirik Johansen
J Immunol 2017 198: 1765-1767 | ImmunoCast

Pillars Article: Mucosal and Glandular Distribution of Immunoglobulin Components: Differential Localization of Free and Bound SC in Secretory Epithelial Cells. J. Immunol. 1974. 112: 1553–1559

Per Brandtzaeg
J Immunol 2017 198: 1768-1774


FOXP3, the Transcription Factor at the Heart of the Rebirth of Immune Tolerance

Jeffrey A. Bluestone
J Immunol 2017 198: 979-980 | ImmunoCast

Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057–1061

Shohei Hori, Takashi Nomura and Shimon Sakaguchi
J Immunol 2017 198: 981-985

Pillars Article: Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells. Nat. Immunol. 2003. 4: 330–336

Jason D. Fontenot, Marc A. Gavin and Alexander Y. Rudensky
J Immunol 2017 198: 986-992

Pillars Article: An Essential Role for Scurfin in CD4+CD25+ T Regulatory Cells. Nat. Immunol. 2003. 4: 337–342

Roli Khattri, Tom Cox, Sue-Ann Yasayko and Fred Ramsdell
J Immunol 2017 198: 993-998


Identification of IgE as the Allergy-Associated Ig Isotype

Fred D. Finkelman
J Immunol 2017 198: 3-4 | ImmunoCast

Pillars Article: Physico-Chemical Properties of Human Reaginic Antibody: IV. Presence of a Unique Immunoglobulin as a Carrier of Reaginic Activity. J. Immunol. 1966. 97: 75–85

Kimishige Ishizaka, Teruko Ishizaka, and Margaret M. Hornbrook
J Immunol 2017 198: 5-15

Pillars Article: Physicochemical Properties of Reaginic Antibody: V. Correlation of Reaginic Activity with γE-Globulin Antibody. J. Immunol. 1966. 97: 840–853

Kimishige Ishizaka, Teruko Ishizaka, and Margaret M. Hornbrook
J Immunol 2017 198: 16-29


The Old One–Two: Solving the Mystery of Cognate Help

Michael P. Cancro
J Immunol 2016 197: 4193-4194 | ImmunoCast

Pillars Article: A 39-kDa Protein on Activated Helper T Cells Binds CD40 and Transduces the Signal for Cognate Activation of B Cells. Proc. Natl. Acad. Sci. 1992. 89: 6550–6554

Randolph J. Noelle, Meenakshi Roy, David M. Shepherd, Ivan Stamenkovico, Jeffrey A. Ledbetter, and Alejandro Aruffo
J Immunol 2016 197: 4195-4199


OKT3 and H57-597: From Discovery, to Commercialization, to the Clinic

Kristin A. Hogquist
J Immunol 2016 197: 3429-3430 | ImmunoCast

Pillars Article: OKT3: A Monoclonal Anti-Human T Lymphocyte Antibody with Potent Mitogenic Properties. J. Immunol. 1980. 124: 2708–2713

Jean P. Van Wauwe, Jan R. De Mey, and Jan G. Goossens
J Immunol 2016 197: 3431-3436

Pillars Article: Characterization of a Monoclonal Antibody Which Detects All Murine αβ T Cell Receptors. J. Immunol. 1989. 142: 2736–2742

Ralph T. Kubo, Willi Born, John W. Kappler, Philippa Marrack, and Michele Pigeon
J Immunol 2016 197: 3437-3443


TLR4: The Winding Road to the Discovery of the LPS Receptor

Jessica L. Murdock and Gabriel Nunez
J Immunol 2016 197: 2561-2562 | ImmunoCast

Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product. J. Immunol. 1999. 162: 3749–3752

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, and Shizuo Akira
J Immunol 2016 197: 2563-2566


IL-10: A Paradigm for Counterregulatory Cytokines

Patricia Castillo and Jay K. Kolls
J Immunol 2016 197: 1529-1530 | ImmunoCast

Pillars Article: IL-10 Acts on the Antigen-presenting Cell to Inhibit Cytokine Production by Thl Cells. J. Immunol. 1991. 146: 3444–3451

David F. Fiorentino, Albert Zlotnik, Paulo Vieira, Timothy R. Mosmann, Maureen Howard, Kevin W. Moore, and Anne O'Garra
J Immunol 2016 197: 1531-1538

Pillars Article: IL-10 Inhibits Cytokine Production by Activated Macrophages. J. Immunol. 1991. 147: 3815–3822

David F. Fiorentino, Albert Zlotnik, Timothy R. Mosmann, Maureen Howard, and Anne O'Garra
J Immunol 2016 197: 1539-1546

Pillars Article: Induction of Tolerance by IL-10-Treated Dendritic Cells. J. Immunol. 1997. 159: 4772–4780

Kerstin Steinbrink, Matthias Wolfl, Helmut Jonuleit, Jurgen Knop, and Alexander H. Enk
J Immunol 2016 197: 1547-1555


Turning on the Lights inside Neutrophils

Robert L. Fairchild
J Immunol 2016 197: 681-682 | ImmunoCast

Pillars Article: Flow Cytometric Studies of Oxidative Product Formation by Neutrophils: A Graded Response to Membrane Stimulation. J. Immunol. 1983. 130: 1910–1917

David A. Bass, J. Wallace Parce, Lawrence R. Dechatelet, Pamela Szejda, Michael C. Seeds, and Michael Thomas
J Immunol 2016 197: 683-690


TCGF: How Much? Oh, and by the Way, How Many?

Frank W. Fitch
J Immunol 2016 197: 3-4 | ImmunoCast

Pillars Article: T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity. J. Immunol. 1978. 120: 2027–2032

Steven Gillis, Mary M. Ferm, Winny Ou, and Kendall A. Smith
J Immunol 2016 197: 5-10


Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role

Anne O'Garra and Leona Gabryšova
J Immunol 2016 196: 4423-4425 | ImmunoCast

Pillars Article: The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells. Cell. 1997. 89: 587–596

Wei-ping Zheng and Richard A. Flavell
J Immunol 2016 196: 4426-4435


Discovery of the γδ TCR: Act II

Willi K. Born and Rebecca L. OBrien
J Immunol 2016 196: 3507-3508 | ImmunoCast

Pillars Article: Identification of a Putative Second T-cell Receptor. Nature. 1986. 322: 145–149

Michael B. Brenner, Joanne McLean, Deno P. Dialynas, Jack L. Strominger, John A. Smith, Frances L. Owen, J. G. Seidman, Stephen Ip, Fred Rosen, and Michael S. Krangel
J Immunol 2016 196: 3509-3513

Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179–181

Ilan Bank, Ronald A. DePinho, Michael B. Brenner, Judy Cassimeris, Frederick W. Alt, and Leonard Chess
J Immunol 2016 196: 3514-3516


Promiscuity Promotes Tolerance

Diane Mathis and Christophe Benoist
J Immunol 2016 196: 2913-2914 | ImmunoCast

Pillars Article: Promiscuous Gene Expression in Medullary Thymic Epithelial Cells Mirrors the Peripheral Self. Nat. Immunol. 2001. 2: 1032–1039

Jens Derbinski, Antje Schulte, Bruno Kyewski, and Ludger Klein
J Immunol 2016 196: 2915-2922


How Thymocytes Achieve Their Fate

Dan R. Littman
J Immunol 2016 196: 1983-1984 | ImmunoCast

Pillars Article: Coreceptor Reversal in the Thymus: Signaled CD4+8+ Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8+ T Cells. Immunity. 2000. 13: 59–71

Enrico Brugnera, Avinash Bhandoola, Ricardo Cibotti, Qing Yu, Terry I. Guinter, Yoshio Yamashita, Susan O. Sharrow, and Alfred Singer
J Immunol 2016 196: 1985-1997


The Secrets of the Class II MHC Peptidome Start To Be Revealed

Emil R. Unanue
J Immunol 2016 196: 939-940 | ImmunoCast

Pillars Article: Sequence Analysis of Peptides Bound to MHC Class II Molecules. Nature. 1991. 353: 622–627

Alexander Yu Rudensky, Paula Preston-Hurlburt, Soon-Cheol Hong, Avlin Barlow, and Charles A. Janeway Jr
J Immunol 2016 196: 941-946


CCR7: Unifying Disparate Journeys to the Lymph Node

Gwendalyn J. Randolph
J Immunol 2016 196: 3-4 | ImmunoCast

Pillars Article: CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs. Cell. 1999. 99: 23–33

Reinhold Forster, Andreas Schubel, Dagmar Breitfeld, Elisabeth Kremmer, Ingrid Renner-Muller, Eckhard Wolf, and Martin Lipp
J Immunol 2016 196: 5-15


Beyond Hypothesis: Direct Evidence That V(D)J Recombination Is Regulated by the Accessibility of Chromatin Substrates

Michael S. Krangel
J Immunol 2015 195: 5103-5105 | ImmunoCast

Pillars Article: Cell Type–Specific Chromatin Structure Determines the Targeting of V(D)J Recombinase Activity In Vitro. Cell. 1996. 85: 887–897

Patricia Stanhope-Baker, Karen M. Hudson, Arthur L. Shaffer, Andrei Constantinescu, and Mark S. Schlissel
J Immunol 2015 195: 5106-5116


The Long (and Sometimes Endless) Road to Murine Lupus Genes

Chandra Mohan
J Immunol 2015 195: 4043-4046 | ImmunoCast

Pillars Article: Polygenic Control of Susceptibility to Murine Systemic Lupus Erythematosus. Immunity. 1994. 1: 219-229

Laurence Morel, Ulrich H. Rudofsky, Jeffrey A. Longmate, Joel Schiffenbauer, and Edward K. Wakeland
J Immunol 2015 195: 4047-4057


Bone Marrow Cell Rejection, MHC, NK Cells, and Missing Self Recognition: Ain’t That Peculiar (with Apologies to Marvin Gaye)

David H. Raulet
J Immunol 2015 195: 2923-2925 | ImmunoCast

Pillars Article: Peculiar Immunobiology of Bone Marrow Allografts: I. Graft Rejection by Irradiated Responder Mice. J Exp Med. 1971. 134: 83–102

Gustavo Cudkowicz and Michael Bennett
J Immunol 2015 195: 2926-2945

Pillars Article: Peculiar Immunobiology of Bone Marrow Allografts: II. Rejection of Parental Grafts by Resistant FI Hybrid Mice. J Exp Med. 1971. 134: 1513–1528

Gustavo Cudkowicz and Michael Bennett
J Immunol 2015 195: 2946-2961


Interference with Virus Infection

Michael Gale Jr.
J Immunol 2015 195: 1909-1910 | ImmunoCast

Pillars Article: Virus Interference. I. The Interferon. Proc R Soc Lond B Biol Sci. 1957. 147: 258-267

A. Isaacs and J. Lindenmann
J Immunol 2015 195: 1911-1920

Pillars Article: Virus Interference. II. Some Properties of Interferon. Proc R Soc Lond B Biol Sci. 1957. 147: 268–273

A. Isaacs, J. Lindenmann, and R. C. Valentine
J Immunol 2015 195: 1921-1926


Masterminding B Cells

Suzanne Cory
J Immunol 2015 195: 763-765 | ImmunoCast

Pillars Article: Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 1999. 401: 556–562

Stephen L. Nutt, Barry Heavey, Antonius G. Rolink, and Meinrad Busslinger
J Immunol 2015 195: 766-772


Citrullination: A Specific Target for the Autoimmune Response in Rheumatoid Arthritis

David A. Fox
J Immunol 2015 195: 5-7 | ImmunoCast

Pillars Article: Citrulline is an Essential Constituent of Antigenic Determinants Recognized by Rheumatoid Arthritis–specific Autoantibodies. J. Clin. Invest. 1998. 101: 273–281

Gerard A. Schellekens, Ben A. W. de Jong, Frank H. J. van den Hoogen, Leo B. A. van de Putte, and Walther J. van Venrooij
J Immunol 2015 195: 8-16


Kill or Be Killed

Edward M. Behrens and Randy Q. Cron
J Immunol 2015 194: 5041-5043 | ImmunoCast

Pillars Article: Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis. Science. 1999. 286: 1957–1959

Susan E. Stepp, Remi Dufourcq-Lagelouse, Francoise Le Deist, Sadhna Bhawan, Stephanie Certain, Porunelloor A. Mathew, Jan-Inge Henter, Michael Bennett, Alain Fischer, Genevieve de Saint Basile, and Vinay Kumar
J Immunol 2015 194: 5044-5046


Seeing Is Believing: Sorting Out Signaling Events at the Immunological Synapse

Janis K. Burkhardt
J Immunol 2015 194: 4059-4060 | ImmunoCast

Pillars Article: Three-Dimensional Segregation of Supramolecular Activation Clusters in T cells. Nature. 1998. 395: 82–86

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CRACking the Code without Rosetta: Molecular Regulation of Calcium-Stimulated Gene Transcription after T Cell Activation

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Staying Alive: T Cell Costimulation, CD28, and Bcl-xL

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Multiple Roles of CD4 and CD8 in T Cell Activation

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Cross-Priming: Its Beginnings

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Blimp-1’s Maiden Flight

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CD4 on the Road to Coreceptor Status

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The Earliest Knockouts

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An Alternative Path for Antigen Presentation: Group 1 CD1 Proteins

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Innate and Adaptive Receptors Interact to Balance Humoral Immunity

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Plugging the Leaky Pre-B Cell Receptor

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The Discovery of Immunological Tolerance: Now More Than Just a Laboratory Solution

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A Crucial Door to the Mast Cell Mystery Knocked In

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Establishing Anergy as a Bona Fide In Vivo Mechanism of B Cell Tolerance

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How Suppressor Cells Led to Anergy, Costimulation, and Beyond

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Turning the Tide of Lymphocyte Costimulation

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The "Bubble Boy" Paradox: An Answer That Led to a Question

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Th1 Fate Determination in CD4+ T Cells: Notice Is Served of the Importance of IL-12!

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IL-4 Production by T Cells: You Need a Little to Get a Lot

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First Demonstration of the Role of TNF in the Pathogenesis of Disease

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Wu and Kabat 1970: A Transforming View of Antibody Diversity

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More Than Just Vanilla

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Peyer’s Patches as the Inductive Site for IgA Responses

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G.O.D.’s Holy Grail: Discovery of the RAG Proteins

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Characterizing MHC-Associated Peptides by Mass Spectrometry

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Controlling the Ir Genes

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A Golden Anniversary: Recognition That Rheumatoid Arthritis Sera Contain Autoantibodies Specific for Determinants on Native IgG Molecules

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When It Comes to CTL Recognition, Size Does Matter

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Discovering the TCR β-Chain by Subtraction

Arthur Weiss
J Immunol 2005 175: 2769-2770

Pillars Article: Isolation of cDNA Clones Encoding T Cell-Specific Membrane-Associated Proteins. Nature, 1984, 308: 149–153.

Stephen M. Hedrick, David I. Cohen, Ellen A. Nielsen, and Mark M. Davis
J Immunol 2005 175: 2771-2775


Peyer’s Patch Germinal Centers: The Elusive Switch Site for IgA

Jerry R. McGhee
J Immunol 2005 175: 1361-1362

Pillars Article: Surface Phenotype of Peyer’s Patch Germinal Center Cells: Implications for the Role of Germinal Centers in B Cell Differentiation. J. Immunol. 1982. 129: 2698–2707.

Eugene C. Butcher, Robert V. Rouse, Robert L. Coffman, Carol N. Nottenburg, Richard R. Hardy, and Irving L. Weissman
J Immunol 2005 175: 1363-1372


The World of Th1/Th2 Subsets: First Proof

Jerry R. McGhee
J Immunol 2005 175: 3-4

Pillars Article: Two Types of Murine Helper T Cell Clone. I. Definition According to Profiles of Lymphokine Activities and Secreted Proteins. J. Immunol., 1986, 136: 2348–2357.

Timothy R. Mosmann, Holly Cherwinski, Martha W. Bond, Martin A. Giedlin, and Robert L. Coffman
J Immunol 2005 175: 5-14


Missing Self, NK Cells, and The White Album

Lewis L. Lanier
J Immunol 2005 174: 6565-6565

Pillars Article: Selective Rejection of H–2-Deficient Lymphoma Variants Suggests Alternative Immune Defence Strategy. Nature, 1986, 391: 675–678

Klas Karre, Hans Gustaf Ljunggren, Gerald Piontek, and Rolf Kiessling
J Immunol 2005 174: 6566-6569


Crossing the Threshold of Lymphocyte Activation

Michael P. Cancro
J Immunol 2005 174: 5159-5160

Pillars Article: The Mechanism of Antigenic Stimulation of Primary and Secondary Clonal Precursor Cells. J. Exp. Med., 1972, 136: 241–260

Norman R. Klinman
J Immunol 2005 174: 5161-5180


Proving Negative Selection in the Thymus

Jonathan Sprent
J Immunol 2005 174: 3841-3842

Pillars Article: T Cell Tolerance by Clonal Elimination in the Thymus. Cell, 1987, 49: 273–280.

John W. Kappler, Neal Roehm, and Philippa Marrack
J Immunol 2005 174: 3843-3850


Monoclonal Antibodies: Producing Magic Bullets by Somatic Cell Hybridization

David H. Margulies
J Immunol 2005 174: 2451-2452

Pillars Article: Continuous cultures of fused cells secreting antibody of predefined specificity. Nature, 1975, 256 (5517): 495–497.

G. Kohler and C. Milstein
J Immunol 2005 174: 2453-2455


First Sighting of the Elusive T Cell Antigen Receptor

Lewis L. Lanier
J Immunol 2005 174: 1143-1143

Pillars Article: Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody. 1982, J. Immunol. 129: 2293–2300.

James P. Allison, Bradley W. McIntyre, and David Bloch
J Immunol 2005 174: 1144-1151


Putting a Face to MHC Restriction

Peter Parham
J Immunol 2005 174: 3-5

Pillars Article: Structure of the human class I histocompatibility antigen, HLA-A2. Nature. 1987. 329: 506-512  

P. J. Bjorkman, M. A. Saper, B. Samraoui, W. S. Bennett, J. L. Strominger, and D. C. Wiley
J Immunol 2005 174: 6-12

Pillars Article: The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature. 1987. 329: 512-518

P. J. Bjorkman, M. A. Saper, B. Samraoui, W. S. Bennett, J. L. Strominger, and D. C. Wiley
J Immunol 2005 174: 13-19


Multiple Genes, One Polypeptide Chain

J. Donald Capra
J Immunol 2004 173: 6501-6502

Pillars Article: An Immunoglobulin Heavy Chain Variable Region Gene Is Generated from Three Segments of DNA: VH, D and JH. Cell, 1980, 19: 981–992.

P. Early, H. Huang, M. Davis, K. Calame, and L. Hood
J Immunol 2004 173: 6503-6514


When Two-Dimensional Structure Led the Way

Norman R. Klinman
J Immunol 2004 173: 5333-5334

Pillars Article: The Covalent Structure of an Entire γG Immunoglobulin Molecule. Proc. Natl. Acad. Sci. USA, 1969, 63: 78–85.

Gerald M. Edelman, Bruce A. Cunningham, W. Einar Gall, Paul D. Gottlieb, Urs Rutishauser, and Myron J. Waxdal
J Immunol 2004 173: 5335-5342


The Birth of Molecular Immunology

Patricia J. Gearhart
J Immunol 2004 173: 4259-4259

Pillars Article: Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc. Natl. Acad. Sci. USA, 1976, 10: 3628-3632

N. Hozumi and S. Tonegawa
J Immunol 2004 173: 4260-4264


Altered Self, Altered World

Michael J. Bevan
J Immunol 2004 173: 2897-2898

Pillars Article: Immunological Surveillance against Altered Self Components by Sensitised T Lymphocytes in Lymphocytic Choriomeningitis. Nature, 1974, 251: 547–548.

Rolf M. Zinkernagel and Peter C. Doherty
J Immunol 2004 173: 2899-2900


Making the Connection: Antibody Responsiveness and MHC Genes

Jack R. Bennink
J Immunol 2004 173: 1499-1499

Pillars Article: Genetic Control of the Antibody Responses: Relationship between Immune Response and Histocompatibility (H-2) Type. Science, 1969, 163:1207–1208

Hugh O. McDevitt and Allen Chinitz
J Immunol 2004 173: 1500-1501


The Beginnings of T-B Collaboration

Jonathan S. Bromberg
J Immunol 2004 173: 7-13

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