From the Current Issue: Feb 2020; 204 (4) [Table of Contents]
There are no new Pillars of Immunology articles in this issue.
From Past Issues:
Glial Cells as Regulators of Neuroimmune Interactions in the Central Nervous System
Jack P. Antel, Burkhard Becher, Samuel K. Ludwin, Alexandre Prat and Francisco J. Quintana
J Immunol 2020 204: 251-255
The Colon as a Major Site of Immunoregulation by CD4+ T Cell Subsets in the Steady State
Alan Sher and Brian L. Kelsall
J Immunol 2019 203: 1683-1684
Assembling the Inflammasome, Piece by Piece
Fiachra Humphries and Katherine A. Fitzgerald
J Immunol 2019 203: 1093-1094 | ImmunoCast
Complement in Motion: The Evolution of CD46 from a Complement Regulator to an Orchestrator of Normal Cell Physiology
M. Kathryn Liszewski and Claudia Kemper
J Immunol 2019 203: 3-5 | ImmunoCast
Mystery Solved: IL-15
Todd A. Fehniger
J Immunol 2019 202: 3125-3126 | ImmunoCast
Unmasking the Mysteries of MYC
Rajeev M. Nepal and Alberto Martini
J Immunol 2019 202: 2517-2518 | ImmunoCast
On the Road to Discovering the Elusive Executioner of Pyroptosis
David E. Place and Thirumala-Devi Kanneganti
J Immunol 2019 202: 1911-1912
Pillars Article: Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol. 2006. 8: 1812–1825
J Immunol 2019 202: 1913-1926
From RAG2 to T Cell Riches and Future Fortunes
Rebecca A. Glynn and Craig H. Bassing
J Immunol 2019 202: 1315-1316 | ImmunoCast
Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825
J Immunol 2019 202: 1317-1320
The Tale of IL-12 and IL-23: A Paradigm Shift
Shabaana A. Khader and Shyamala Thirunavukkarasu
J Immunol 2019 202: 629-630 | ImmunoCast
Attracting Attention: Discovery of IL-8/CXCL8 and the Birth of the Chemokine Field
Bethany B. Moore and Steven L. Kunkel
J Immunol 2019 202: 3-4 | ImmunoCast
Pillars Article: Purification of a Human Monocyte-Derived Neutrophil Chemotactic Factor That Has Peptide Sequence Similarity to Other Host Defense Cytokines. Proc. Natl. Acad. Sci. USA 1987. 84: 9233–9237
J Immunol 2019 202: 5-9
Opening the Black Box of Immunosuppression
Mark H. Kaplan
J Immunol 2018 201: 3147-3148 | ImmunoCast
Pillars Article: Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation. Science. 1989. 246: 1617–1620
J Immunol 2018 201: 3149-3152
The Common Key to Class-Switch Recombination and Somatic Hypermutation: Discovery of AID and Its Role in Antibody Gene Diversification
Rebecca J. Leeman-Neill, Junghyun Lim and Uttiya Basu
J Immunol 2018 201: 2527-2529 | ImmunoCast
Pillars Article: Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme. Cell. 2000. 102: 553–563
J Immunol 2018 201: 2530-2540
How Superantigens Bind MHC
Luc Van Kaer
J Immunol 2018 201: 1817-1818 | ImmunoCast
Pillars Article: Three-Dimensional Structure of a Human Class II Histocompatibility Molecule Complexed with Superantigen. Nature. 1994. 368: 711–718
J Immunol 2018 201: 1819-1826
A Convergent Immunological Holy Trinity of Adaptive Immunity in Lampreys: Discovery of the Variable Lymphocyte Receptors
Martin F. Flajnik
J Immunol 2018 201: 1331-1335 | ImmunoCast
Pillars Article: Somatic Diversification of Variable Lymphocyte Receptors in the Agnathan Sea Lamprey. Nature. 2004. 430: 174–180
J Immunol 2018 201: 1336-1342
From Cancer Immune Surveillance to Cancer Immunoediting: Birth of Modern Immuno-Oncology
Wolf H. Fridman
J Immunol 2018 201: 825-826 | ImmunoCast
Pillars Article: IFNγ and Lymphocytes Prevent Primary Tumour Development and Shape Tumour Immunogenicity. Nature. 2001. 410: 1107–1111
J Immunol 2018 201: 827-831
Where Have All the Flowers Gone?
Philippa Marrack
J Immunol 2018 201: 5-6 | ImmunoCast
Pillars Article: T-Cell Apoptosis Detected In Situ during Positive and Negative Selection in the Thymus. Nature. 1994. 372: 100–103
J Immunol 2018 201: 7-10
Discovering the Cause of Wiskott–Aldrich Syndrome and Laying the Foundation for Understanding Immune Cell Structuring
Emily M. Mace and Jordan S. Orange
J Immunol 2018 200: 3667-3670 | ImmunoCast
Pillars Article: Isolation of a Novel Gene Mutated in Wiskott-Aldrich Syndrome. Cell. 1994. 78: 635–644
J Immunol 2018 200: 3671-3680
Specialized Antitumor Functions for Skin γδ T Cells
Wendy L. Havran
J Immunol 2018 200: 2229-2230 | ImmunoCast
Pillars Article: Regulation of Cutaneous Malignancy by γδ T Cells. Science. 2001. 294: 605–609
J Immunol 2018 200: 3031-3035
NKG2D–MICA Interaction: A Paradigm Shift in Innate Recognition
Mathieu Bléry and Eric Vivier
J Immunol 2018 200: 2229-2230 | ImmunoCast
Pillars Article: Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science. 1999. 285: 727–729
J Immunol 2018 200: 2231-2233
The Chemical Elucidation of Slow-Reacting Substance: Bronchospasm and Beyond
Marc Peters-Golden
J Immunol 2018 200: 1535-1537 | ImmunoCast
Pillars Article: Leukotriene C: A Slow-Reacting Substance from Murine Mastocytoma Cells. Proc. Natl. Acad. Sci. USA. 1979. 76: 4275–4279
J Immunol 2018 200: 1538-1542
Dendritic Cells on the Way to Glory
Sebastian Amigorena
J Immunol 2018 200: 885-886 | ImmunoCast
Pillars Article: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 1994. 179:1109–1118
J Immunol 2018 200: 887-896
The Reign of Antibodies: A Celebration of and Tribute to Michael Potter and His Homogeneous Immunoglobulin Workshops
Patricia J. Gearhart, Beverly A. Mock, Rafael Casellas and Michael P. Cancro
J Immunol 2018 200: | ImmunoCast
Pillars Article: Evidence for Amino Acid Sequence Differences among Proteins Resembling the L-chain Subunits of Immunoglobulins. J. Mol. Biol. 1965. 12: 81–87
J Immunol 2018 200: 27-37
Critical Functions of IRF4 in B and T Lymphocytes
James Hagman
J Immunol 2017 199: | ImmunoCast
Pillars Article: Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function. Science. 1997. 275: 540–543
J Immunol 2017 199: 3717-3720
Stacking the Deck: Studies of Patients with Multiple Autoimmune Diseases Propelled Our Understanding of Type 1 Diabetes as an Autoimmune Disease
Jane H. Buckner and Carla J. Greenbaum
J Immunol 2017 199: | ImmunoCast
Pillars Article: Islet-cell Antibodies in Diabetes Mellitus with Autoimmune Polyendocrine Deficiencies. Lancet. 1974. 304: 1279-1283
J Immunol 2017 199: 3014-3018
Pillars Article: Antibodies to Pancreatic Islet Cells in Insulin-dependent Diabetics with Coexistent Autoimmune Disease. Lancet. 1974. 304: 1529-1531
J Immunol 2017 199: 3019-3021
M1 Means Kill; M2 Means Heal
Klaus Ley
J Immunol 2017 199: | ImmunoCast
Pillars Article: M-1/M-2 Macrophages and the Th1/Th2 Paradigm. J. Immunol. 2000. 164: 6166–6173
J Immunol 2017 199: 2194-2201
SAP and Lessons Learned from a Primary Immunodeficiency
Jennifer L. Cannons and Pamela L. Schwartzberg
J Immunol 2017 199: | ImmunoCast
Pillars Article: The X-Linked Lymphoproliferative Disease Gene Product SAP Regulates Signals Induced through the Co-Receptor SLAM. Nature. 1998. 395: 462–469
J Immunol 2017 199: 1534-1541
Defining the Kinetics, Phenotype, and Function of T Cells Induced by Mycobacterium tuberculosis: Pillar of Immunity to Tuberculosis
Andrea M. Cooper
J Immunol 2017 199: | ImmunoCast
Pillars Article: The Kinetics of Emergence and Loss of Mediator T Lymphocytes Acquired in Response to Infection with Mycobacterium Tuberculosis. J. Immunol. 1987. 138: 293–298
J Immunol 2017 199: 833-838
Access Guide to Antigen Receptor Genes
Ranjan Sen
J Immunol 2017 199: | ImmunoCast
Pillars Article: A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination. Science. 2000. 287: 495-498
J Immunol 2017 199: 5-8
Monocyte-Derived Dendritic Cells: A Transendothelial Trip Launches the Quest To Understand Heterogeneity in the APC Family
Gabrielle T. Belz
J Immunol 2017 198: | ImmunoCast
Pillars Article: Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking. Science. 1998. 282: 480–483
J Immunol 2017 198: 4191-4194
T Cell–Transfer Experimental Autoimmune Encephalomyelitis: Pillar of Multiple Sclerosis and Autoimmunity
Reinhard Hohlfeld and Lawrence Steinman
J Immunol 2017 198: | ImmunoCast
Pillars Article: The Rapid Isolation of Clonable Antigen-specific T Lymphocyte Lines Capable of Mediating Autoimmune Encephalomyelitis. Eur J Immunol. 1981.11: 195-199 Nature. 1984. 309: 763–767
J Immunol 2017 198:
The Cloning of GM-CSF
Glenn Dranoff
J Immunol 2017 198: | ImmunoCast
Pillars Article: Molecular Cloning of cDNA Encoding a Murine Haematopoietic Growth Regulator, Granulocyte—Macrophage Colony Stimulating Factor. Nature. 1984. 309: 763–767
J Immunol 2017 198:
Two Cells, One Antibody: The Discovery of the Cellular Origins and Transport of Secretory IgA
Charlotte S. Kaetzel, Jiri Mestecky and Finn-Eirik Johansen
J Immunol 2017 198: 1765-1767 | ImmunoCast
Pillars Article: Mucosal and Glandular Distribution of Immunoglobulin Components: Differential Localization of Free and Bound SC in Secretory Epithelial Cells. J. Immunol. 1974. 112: 1553–1559
Per Brandtzaeg
J Immunol 2017 198: 1768-1774
FOXP3, the Transcription Factor at the Heart of the Rebirth of Immune Tolerance
Jeffrey A. Bluestone
J Immunol 2017 198: 979-980 | ImmunoCast
Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057–1061
Shohei Hori, Takashi Nomura and Shimon Sakaguchi
J Immunol 2017 198: 981-985
Pillars Article: Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells. Nat. Immunol. 2003. 4: 330–336
Jason D. Fontenot, Marc A. Gavin and Alexander Y. Rudensky
J Immunol 2017 198: 986-992
Pillars Article: An Essential Role for Scurfin in CD4+CD25+ T Regulatory Cells. Nat. Immunol. 2003. 4: 337–342
Roli Khattri, Tom Cox, Sue-Ann Yasayko and Fred Ramsdell
J Immunol 2017 198: 993-998
Identification of IgE as the Allergy-Associated Ig Isotype
Fred D. Finkelman
J Immunol 2017 198: 3-4 | ImmunoCast
Pillars Article: Physico-Chemical Properties of Human Reaginic Antibody: IV. Presence of a Unique Immunoglobulin as a Carrier of Reaginic Activity. J. Immunol. 1966. 97: 75–85
Kimishige Ishizaka, Teruko Ishizaka, and Margaret M. Hornbrook
J Immunol 2017 198: 5-15
Pillars Article: Physicochemical Properties of Reaginic Antibody: V. Correlation of Reaginic Activity with γE-Globulin Antibody. J. Immunol. 1966. 97: 840–853
Kimishige Ishizaka, Teruko Ishizaka, and Margaret M. Hornbrook
J Immunol 2017 198: 16-29
The Old One–Two: Solving the Mystery of Cognate Help
Michael P. Cancro
J Immunol 2016 197: 4193-4194 | ImmunoCast
Pillars Article: A 39-kDa Protein on Activated Helper T Cells Binds CD40 and Transduces the Signal for Cognate Activation of B Cells. Proc. Natl. Acad. Sci. 1992. 89: 6550–6554
Randolph J. Noelle, Meenakshi Roy, David M. Shepherd, Ivan Stamenkovico, Jeffrey A. Ledbetter, and Alejandro Aruffo
J Immunol 2016 197: 4195-4199
OKT3 and H57-597: From Discovery, to Commercialization, to the Clinic
Kristin A. Hogquist
J Immunol 2016 197: 3429-3430 | ImmunoCast
Pillars Article: OKT3: A Monoclonal Anti-Human T Lymphocyte Antibody with Potent Mitogenic Properties. J. Immunol. 1980. 124: 2708–2713
Jean P. Van Wauwe, Jan R. De Mey, and Jan G. Goossens
J Immunol 2016 197: 3431-3436
Pillars Article: Characterization of a Monoclonal Antibody Which Detects All Murine αβ T Cell Receptors. J. Immunol. 1989. 142: 2736–2742
Ralph T. Kubo, Willi Born, John W. Kappler, Philippa Marrack, and Michele Pigeon
J Immunol 2016 197: 3437-3443
TLR4: The Winding Road to the Discovery of the LPS Receptor
Jessica L. Murdock and Gabriel Nunez
J Immunol 2016 197: 2561-2562 | ImmunoCast
Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product. J. Immunol. 1999. 162: 3749–3752
Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, and Shizuo Akira
J Immunol 2016 197: 2563-2566
IL-10: A Paradigm for Counterregulatory Cytokines
Patricia Castillo and Jay K. Kolls
J Immunol 2016 197: 1529-1530 | ImmunoCast
Pillars Article: IL-10 Acts on the Antigen-presenting Cell to Inhibit Cytokine Production by Thl Cells. J. Immunol. 1991. 146: 3444–3451
David F. Fiorentino, Albert Zlotnik, Paulo Vieira, Timothy R. Mosmann, Maureen Howard, Kevin W. Moore, and Anne O'Garra
J Immunol 2016 197: 1531-1538
Pillars Article: IL-10 Inhibits Cytokine Production by Activated Macrophages. J. Immunol. 1991. 147: 3815–3822
David F. Fiorentino, Albert Zlotnik, Timothy R. Mosmann, Maureen Howard, and Anne O'Garra
J Immunol 2016 197: 1539-1546
Pillars Article: Induction of Tolerance by IL-10-Treated Dendritic Cells. J. Immunol. 1997. 159: 4772–4780
Kerstin Steinbrink, Matthias Wolfl, Helmut Jonuleit, Jurgen Knop, and Alexander H. Enk
J Immunol 2016 197: 1547-1555
Turning on the Lights inside Neutrophils
Robert L. Fairchild
J Immunol 2016 197: 681-682 | ImmunoCast
Pillars Article: Flow Cytometric Studies of Oxidative Product Formation by Neutrophils: A Graded Response to Membrane Stimulation. J. Immunol. 1983. 130: 1910–1917
David A. Bass, J. Wallace Parce, Lawrence R. Dechatelet, Pamela Szejda, Michael C. Seeds, and Michael Thomas
J Immunol 2016 197: 683-690
TCGF: How Much? Oh, and by the Way, How Many?
Frank W. Fitch
J Immunol 2016 197: 3-4 | ImmunoCast
Pillars Article: T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity. J. Immunol. 1978. 120: 2027–2032
Steven Gillis, Mary M. Ferm, Winny Ou, and Kendall A. Smith
J Immunol 2016 197: 5-10
Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role
Anne O'Garra and Leona Gabryšova
J Immunol 2016 196: 4423-4425 | ImmunoCast
Pillars Article: The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells. Cell. 1997. 89: 587–596
Wei-ping Zheng and Richard A. Flavell
J Immunol 2016 196: 4426-4435
Discovery of the γδ TCR: Act II
Willi K. Born and Rebecca L. OBrien
J Immunol 2016 196: 3507-3508 | ImmunoCast
Pillars Article: Identification of a Putative Second T-cell Receptor. Nature. 1986. 322: 145–149
Michael B. Brenner, Joanne McLean, Deno P. Dialynas, Jack L. Strominger, John A. Smith, Frances L. Owen, J. G. Seidman, Stephen Ip, Fred Rosen, and Michael S. Krangel
J Immunol 2016 196: 3509-3513
Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179–181
Ilan Bank, Ronald A. DePinho, Michael B. Brenner, Judy Cassimeris, Frederick W. Alt, and Leonard Chess
J Immunol 2016 196: 3514-3516
Promiscuity Promotes Tolerance
Diane Mathis and Christophe Benoist
J Immunol 2016 196: 2913-2914 | ImmunoCast
Pillars Article: Promiscuous Gene Expression in Medullary Thymic Epithelial Cells Mirrors the Peripheral Self. Nat. Immunol. 2001. 2: 1032–1039
Jens Derbinski, Antje Schulte, Bruno Kyewski, and Ludger Klein
J Immunol 2016 196: 2915-2922
How Thymocytes Achieve Their Fate
Dan R. Littman
J Immunol 2016 196: 1983-1984 | ImmunoCast
Pillars Article: Coreceptor Reversal in the Thymus: Signaled CD4+8+ Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8+ T Cells. Immunity. 2000. 13: 59–71
Enrico Brugnera, Avinash Bhandoola, Ricardo Cibotti, Qing Yu, Terry I. Guinter, Yoshio Yamashita, Susan O. Sharrow, and Alfred Singer
J Immunol 2016 196: 1985-1997
The Secrets of the Class II MHC Peptidome Start To Be Revealed
Emil R. Unanue
J Immunol 2016 196: 939-940 | ImmunoCast
Pillars Article: Sequence Analysis of Peptides Bound to MHC Class II Molecules. Nature. 1991. 353: 622–627
Alexander Yu Rudensky, Paula Preston-Hurlburt, Soon-Cheol Hong, Avlin Barlow, and Charles A. Janeway Jr
J Immunol 2016 196: 941-946
CCR7: Unifying Disparate Journeys to the Lymph Node
Gwendalyn J. Randolph
J Immunol 2016 196: 3-4 | ImmunoCast
Pillars Article: CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs. Cell. 1999. 99: 23–33
Reinhold Forster, Andreas Schubel, Dagmar Breitfeld, Elisabeth Kremmer, Ingrid Renner-Muller, Eckhard Wolf, and Martin Lipp
J Immunol 2016 196: 5-15
Beyond Hypothesis: Direct Evidence That V(D)J Recombination Is Regulated by the Accessibility of Chromatin Substrates
Michael S. Krangel
J Immunol 2015 195: 5103-5105 | ImmunoCast
Pillars Article: Cell Type–Specific Chromatin Structure Determines the Targeting of V(D)J Recombinase Activity In Vitro. Cell. 1996. 85: 887–897
Patricia Stanhope-Baker, Karen M. Hudson, Arthur L. Shaffer, Andrei Constantinescu, and Mark S. Schlissel
J Immunol 2015 195: 5106-5116
The Long (and Sometimes Endless) Road to Murine Lupus Genes
Chandra Mohan
J Immunol 2015 195: 4043-4046 | ImmunoCast
Pillars Article: Polygenic Control of Susceptibility to Murine Systemic Lupus Erythematosus. Immunity. 1994. 1: 219-229
Laurence Morel, Ulrich H. Rudofsky, Jeffrey A. Longmate, Joel Schiffenbauer, and Edward K. Wakeland
J Immunol 2015 195: 4047-4057
Bone Marrow Cell Rejection, MHC, NK Cells, and Missing Self Recognition: Ain’t That Peculiar (with Apologies to Marvin Gaye)
David H. Raulet
J Immunol 2015 195: 2923-2925 | ImmunoCast
Pillars Article: Peculiar Immunobiology of Bone Marrow Allografts: I. Graft Rejection by Irradiated Responder Mice. J Exp Med. 1971. 134: 83–102
Gustavo Cudkowicz and Michael Bennett
J Immunol 2015 195: 2926-2945
Pillars Article: Peculiar Immunobiology of Bone Marrow Allografts: II. Rejection of Parental Grafts by Resistant FI Hybrid Mice. J Exp Med. 1971. 134: 1513–1528
Gustavo Cudkowicz and Michael Bennett
J Immunol 2015 195: 2946-2961
Interference with Virus Infection
Michael Gale Jr.
J Immunol 2015 195: 1909-1910 | ImmunoCast
Pillars Article: Virus Interference. I. The Interferon. Proc R Soc Lond B Biol Sci. 1957. 147: 258-267
A. Isaacs and J. Lindenmann
J Immunol 2015 195: 1911-1920
Pillars Article: Virus Interference. II. Some Properties of Interferon. Proc R Soc Lond B Biol Sci. 1957. 147: 268–273
A. Isaacs, J. Lindenmann, and R. C. Valentine
J Immunol 2015 195: 1921-1926
Masterminding B Cells
Suzanne Cory
J Immunol 2015 195: 763-765 | ImmunoCast
Pillars Article: Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 1999. 401: 556–562
Stephen L. Nutt, Barry Heavey, Antonius G. Rolink, and Meinrad Busslinger
J Immunol 2015 195: 766-772
Citrullination: A Specific Target for the Autoimmune Response in Rheumatoid Arthritis
David A. Fox
J Immunol 2015 195: 5-7 | ImmunoCast
Pillars Article: Citrulline is an Essential Constituent of Antigenic Determinants Recognized by Rheumatoid Arthritis–specific Autoantibodies. J. Clin. Invest. 1998. 101: 273–281
Gerard A. Schellekens, Ben A. W. de Jong, Frank H. J. van den Hoogen, Leo B. A. van de Putte, and Walther J. van Venrooij
J Immunol 2015 195: 8-16
Kill or Be Killed
Edward M. Behrens and Randy Q. Cron
J Immunol 2015 194: 5041-5043 | ImmunoCast
Pillars Article: Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis. Science. 1999. 286: 1957–1959
Susan E. Stepp, Remi Dufourcq-Lagelouse, Francoise Le Deist, Sadhna Bhawan, Stephanie Certain, Porunelloor A. Mathew, Jan-Inge Henter, Michael Bennett, Alain Fischer, Genevieve de Saint Basile, and Vinay Kumar
J Immunol 2015 194: 5044-5046
Seeing Is Believing: Sorting Out Signaling Events at the Immunological Synapse
Janis K. Burkhardt
J Immunol 2015 194: 4059-4060 | ImmunoCast
Pillars Article: Three-Dimensional Segregation of Supramolecular Activation Clusters in T cells. Nature. 1998. 395: 82–86
Colin R. F. Monks, Benjamin A. Freiberg, Hannah Kupfer, Noah Sciaky, and Abraham Kupfer
J Immunol 2015 194: 4061-4065
Pillars Article: The Immunological Synapse: A Molecular Machine Controlling T Cell Activation. Science. 1999. 285: 221–227
Arash Grakoui, Shannon K. Bromley, Cenk Sumen, Mark M. Davis, Andrey S. Shaw, Paul M. Allen, and Michael L. Dustin
J Immunol 2015 194: 4066-4072
T-bet Transcendent: Unmasking the Faces of Multifarious Immunity
Steven L. Reiner
J Immunol 2015 194: 2959-2960 | ImmunoCast
Pillars Article: A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment. Cell. 2000. 100: 655–669
Susanne J. Szabo, Sean T. Kim, Gina L. Costa, Xiankui Zhang, C. Garrison Fathman, and Laurie H. Glimcher
J Immunol 2015 194: 2961-2975
The DNA Deamination Model of Somatic Antibody Diversification
Klaus Rajewsky
J Immunol 2015 194: 2041-2042 | ImmunoCast
Pillars Article: AID Mutates E. coli Suggesting a DNA Deamination Mechanism for Antibody Diversification. Nature. 2002. 418: 99–103
Svend K. Petersen-Mahrt, Reuben S. Harris, and Michael S. Neuberger
J Immunol 2015 194: 2043-2047
Laying Bare the Nude Mouse Gene
Graham Anderson and Nicholas I. McCarthy
J Immunol 2015 194: 847-848 | ImmunoCast
Pillars Article: New Member of the Winged-Helix Protein Family Disrupted In Mouse And Rat Nude Mutations. Nature. 1994. 372: 103-107
Michael Nehls, Dietmar Pfeifer, Michael Schorpp, Hans Hedrich, and Thomas Boehm
J Immunol 2015 194: 849-853
Not Second Class: The First Class II MHC Crystal Structure
Pamela J. Bjorkman
J Immunol 2015 194: 3-4 | ImmunoCast
Pillars Article: Three-Dimensional Structure of the Human Class II Histocompatibility Antigen HLA-DR1. Nature. 1993. 364: 33–39
Jerry H. Brown, Theodore S. Jardetzky, Joan C. Gorga, Lawrence J. Stern, Robert G. Urban, Jack L. Strominger, and Don C. Wiley
J Immunol 2015 194: 5-11
Identification and Quantitation of Superoxide Anion: Essential Steps in Elucidation of the Phagocyte "Respiratory Burst"
William M. Nauseef
J Immunol 2014 193: 5357-5358 | ImmunoCast
Pillars Article: Biological Defense Mechanisms. The Production by Leukocytes of Superoxide, A Potential Bactericidal Agent. J. Clin. Invest. 1973. 52: 741–744
Bernard M. Babior, Ruby S. Kipnes, and John T. Curnutte
J Immunol 2014 193: 5359-5362
Antigen Receptor Kinase Two-Step
Lawrence P. Kane
J Immunol 2014 193: 4277-4278 | ImmunoCast
Pillars Article: Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine kinases. Science. 1994. 263: 1136–1139
Makio Iwashima, Bryan A. Irving, Nicolai S. C. van Oers, Andrew C. Chan, and Arthur Weiss
J Immunol 2014 193: 4279-4282
Macrophage Activation as an Effector Mechanism for Cell-Mediated Immunity
Vincent C. Tam and Alan Aderem
J Immunol 2014 193: 3183-3184 | ImmunoCast
Pillars Article: Cellular Resistance to Infection. J. Exp. Med. 1962. 116: 381–406
G. B. Mackaness
J Immunol 2014 193: 3185-3221
Pillars Article: The Immunological Basis of Acquired Cellular Resistance. J. Exp. Med. 1964. 120: 105–120
G. B. Mackaness
J Immunol 2014 193: 3222-3237
Just the FACS
Lewis L. Lanier
J Immunol 2014 193: 2043-2044 | ImmunoCast
Pillars Article: Cell Sorting: Automated Separation of Mammalian Cells as a Function of Intracellular Fluorescence. Science. 1969. 166: 747–749
H. R. Hulett, W. A. Bonner, Janet Barrett, and Leonard A. Herzenberg
J Immunol 2014 193: 2045-2047
Pillars Article: Demonstration That Antigen-Binding Cells Are Precursors of Antibody-Producing Cells After Purification with a Fluorescence-Activated Cell Sorter. Proc. Natl. Acad. Sci. 1972. 69: 1934–1938
M. H. Julius, T. Masuda, and L. A. Herzenberg
J Immunol 2014 193: 2048-2052
When Less Is More: T Lymphocyte Populations with Restricted Antigen Receptor Diversity
Mitchell Kronenberg
J Immunol 2014 193: 975-976 | ImmunoCast
Pillars Article: Analysis of T Cell Antigen Receptor (TCR) Expression by Human Peripheral Blood CD4–8– α/β T Cells Demonstrates Preferential Use of Several Vβ Genes and an Invariant TCR α Chain. J. Exp. Med. 1993. 178: 1–16
Steven Porcelli, Courtland E. Yockey, Michael B. Brenner, and Steven P. Balk
J Immunol 2014 193: 977-992
Pillars Article: Homogenous Junctional Sequence of the V14+ T-Cell Antigen Receptor α Chain Expanded in Unprimed Mice. Proc. Natl. Acad. Sci. U.S.A. 1990. 87: 5248–5252
Haruhiko Koseki, Kenji Imai, Fumiaki Nakayama, Toshihiko Sado, Kazuro Moriwaki, and Masaru Taniguchi
J Immunol 2014 193: 993-997
Hunting Autoimmune Disease Genes in NOD: Early Steps on a Long Road to Somewhere Important (Hopefully)
Edward K. Wakeland
J Immunol 2014 193: 3-6
Pillars Article: Genetic Analysis of Autoimmune Type 1 Diabetes Mellitus in Mice. Nature. 1991. 351: 542-547
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