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Comment on “B Cell Depletion Enhances T Regulatory Cell Activity Essential in the Suppression of Arthritis”

Ting-Yu Wang, Fei-Hua Wu and Zhi-Gui Jin
J Immunol January 15, 2012, 188 (2) 519; DOI: https://doi.org/10.4049/jimmunol.1190084
Ting-Yu Wang
Department of Pharmacy, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, The People's Republic of China
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Fei-Hua Wu
Department of Pharmacy, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, The People's Republic of China
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Zhi-Gui Jin
Department of Pharmacy, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, The People's Republic of China
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We read the interesting article by Hamel et al. (1), which provides encouraging data on the role of B cells in arthritis. We suggest that increasing T regulatory cells (Tregs) reveals a novel mechanism of B cell depletion in rheumatoid arthritis (RA) therapy.

B cells play a pivotal role in the pathogenesis of RA through autoantibody production, chemokine/cytokine secretion, and inhibiting autoreactive T cell responses (2). Although a series of treatment regimens that affect B cells was developed (3), the exact mechanism for the efficacy of B cell-depletion therapy remains unclear. The depletion of B cells with a decrease in autoantibodies in RA does not necessarily correlate with the clinical outcome, indicating that mechanisms other than producing Abs are in operation. Recently, Yeo et al. (4) identified B cells as the main source of receptor activator of NF-κB ligand, which contributes to osteoclast activation and bone destruction. Interestingly, Hamel et al. (1) first correlated B cell depletion with the improvement of Tregs, which can inhibit osteoclast formation and activation (5), and with other regulatory mechanisms. The authors found that during proteoglycan-induced arthritis (PGIA), B cell depletion strikingly increased Tregs and decreased the severity of arthritis. In addition, both Tregs and B cell depletion restored proteoglycan-induced arthritis, although the resurgent autoantibody response was absent.

Collectively, B cell depletion could be used for controlling arthritis by improving Tregs. Better insights into the role of B cell depletion in Treg-mediated osteoclast suppression could result in innovative therapies for RA and other bone-destructive diseases.

  • Copyright © 2012 by The American Association of Immunologists, Inc.

References

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    11. et al
    . 2010. Regulatory T cells protect from local and systemic bone destruction in arthritis. J. Immunol. 184: 7238–7246.

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