Table I. Natural and induced IEL subsets detected in mice fed an NCD or HFD
Natural/InducedNCDHFD
Percentage of γδ T cells
 CD4/CD8Natural IEL8.0 ± 0.916.0 ± 1.6
 CD8ααNatural IEL88.0 ± 1.380.0 ± 1.6
Percentage of αβ T cells
 CD4/CD8Natural IEL7.9 ± 2.513.6 ± 3.3
 CD8ααNatural IEL47.6 ± 2.351.8 ± 2.6
 CD8αβInduced IEL20.5 ± 2.420.1 ± 2.6
 CD4+Induced IEL12.9 ± 1.811.2 ± 1.8
 CD4+/CD8αInduced IEL10.8 ± 1.63.1 ± 0.6
  • IEL were isolated from mice administered an NCD or HFD for 14–20 wk. Subsets were examined by flow cytometry. Each dataset represents the average of 22 mice. Error represents SEM. Bold numbers signify p < 0.01.