Table I. The top 10 most differentially expressed genes in GM-MDM versus MDM for each GO category
Gene SymbolDescriptionFold Change: GM versus M
Immune response
 CYP27B1Cytochrome P450, family 27, subfamily B, polypeptide 147.2
 CD226CD226 molecule11.9
 CTSWCathepsin W10.5
 CCL22Chemokine (C-C motif) ligand 229.7
 BNIP3BCL2/adenovirus E1B 19-kDa interacting protein 3−10.0
 CADM1Cell adhesion molecule 1−11.8
 SECTM1Secreted and transmembrane 1−15.3
 THBS1Thrombospondin 1−16.2
 CD28CD28 molecule−40.6
Receptor activity
 TACSTD2Tumor-associated calcium signal transducer 271.8
 CCR6Chemokine (C-C motif) receptor 639.4
 GUCY1B3Guanylate cyclase 1, soluble, β 332.1
 GPR114G protein-coupled receptor 11420.3
 GP1BAGlycoprotein Ib (platelet), α polypeptide17.2
 TNFRSF8TNFR superfamily, member 8−17.3
 ALKAnaplastic lymphoma kinase−21.1
 EDG1Endothelial differentiation G protein-coupled receptor 1−28.2
Cell adhesion
 CLDN14Claudin 1425.2
 SORBS1Sorbin and SH3 domain containing 122.2
 CDH17Cadherin 1715.7
 PTPRFProtein tyrosine phosphatase, receptor type, F14.4
 PTPRKProtein tyrosine phosphatase, receptor type, K13.6
 RND3Rho family GTPase 3−12.5
 FBLN5Fibulin 5−19.0
 NRG1Neuregulin 1−21.5
 CD93CD93 molecule−40.4
 DLL1δ-like 1−119.8
 IGFBP5Insulin-like growth factor binding protein 531.4
 EDN1Endothelin 128.3
 CCL24Chemokine (C-C motif) ligand 2428.1
 PDGFRBPlatelet-derived growth factor receptor, β polypeptide12.8
 CCL5Chemokine (C-C motif) ligand 512.8
 F3Coagulation factor III11.3
 CXCR4Chemokine (C-X-C motif) receptor 4−18.6
 EDNRBEndothelin receptor type B−53.7
 IGF1Insulin-like growth factor 1−56.0
Extracellular region
 CCL1Chemokine (C-C motif) ligand 1129.2
 INHBAInhibin, β A112.0
 IGFBP2Insulin-like growth factor binding protein 217.7
 FLT1fms-related tyrosine kinase 114.6
 PRG2Proteoglycan 213.8
 PRSSL1Protease, serine-like 113.0
 DKK2Dickkopf homolog 212.9
 CFDComplement factor D−18.6
 LOXL1Lysyl oxidase-like 1−22.2
 ADORA1Adenosine A1 receptor7.7
 SFTPDSurfactant, pulmonary-associated protein D5.2
 GATA2GATA binding protein 24.7
 PDLIM7PDZ and LIM domain 74.6
 LDLRAP1Low-density lipoprotein receptor adaptor protein 14.6
 FOLR1Folate receptor 13.9
 CAV1Caveolin 13.5
 ADRB2Adrenergic, β-2-, receptor−3.4
 MSR1Macrophage scavenger receptor 1−4.1
 ITSN1Intersectin-1 (SH3 domain-containing protein 1A)−6.0