Table II. The role of Treg-derived IL-9 on mouse anti-rabbit IgG Ab titres and renal inflammatory cell infiltrates after Treg transfer
GroupsControlwt TregsIL-9 ko Tregs
Mouse anti-rabbit IgG (OD450)0.293 ± 0.0400.354 ± 0.1220.236 ± 0.060
CD4+ cells (no. per 6 Hpf)30.0 ± 16.212.4 ± 4.5a33.0 ± 5.5
F4/80+ cells (score)3.38 ± 0.541.90 ± 0.26a,b3.40 ± 0.17
CD68+ cells (score)3.25 ± 0.281.80 ± 0.33b3.00 ± 0.37
  • Rabbit anti-mouse IgGs were evaluated in the serum of mice of the three different groups (n = 5 per group) 14 d after induction of NTS. The infiltration of CD4+, F4/80+, and CD68+ cells is given. The data are presented as mean ± SEM.

  • a p < 0.025 when comparing the wt Tregs and IL-9–deficient Tregs group.

  • b p < 0.025 between the control T cell- and the Treg-injected group.

  • ko, knockout.