Table I. The role of systemic IL-9 blockade on renal inflammatory cell infiltrates after Treg transfer
GroupsControlTregsTregs + Anti–IL-9
CD4+ cells (no. per 6 Hpf)54.8 ± 9.614.2 ± 3.5a21.8 ± 3.4
F4/80+ cells (score)1.05 ± 0.270.45 ± 0.08a,b0.75 ± 0.07
CD68+ cells (score)1.75 ± 0.400.55 ± 0.11a0.88 ± 0.21
  • The infiltration of CD4+, F4/80+, and CD68+ cells was evaluated in the kidneys of the respective animals (n = 5 per group) 14 d after induction of NTS. The data are presented as mean ± SEM.

  • a p < 0.025 between the control T cell and the Treg group

  • b p < 0.025 when the Tregs and Tregs + anti–IL-9 group are compared.