Table I. Characteristics of HLA-B*27+ individuals at enrollment and end point visits
At Study EntryAt End Point
PIDAge (y)Infected with HIV (y)Plasma HIV RNA (copies/ml)CD4+ T Cell Count (cells/μl)Sequence at Gag aa 263–272: WT Sequence KRWIILGLNKaFollow-up (y)Plasma HIV RNA (copies/ml)CD4+ T Cell Count (cells/μl)Sequence at Gag aa 263-272: WT Sequence KRWIILGLNKa
LT14110620651-----M---- (16)1519,900464-----M---- (15)
R--------- (4)-----I---- (5)
LT238921,000510-----M---- (20)1021,000396-----M---- (14)
-G-------- (4)
-K--VI---- (2)
LT3401252,000651-----M---- (20)19>75,000247-G-------- (18)
-G-------N (2)
LT44794,800532-K--VI---- (4)129,600504-K--VI---- (6)
LT531973,000644---------- (20)969,000630-----M---- (15)
---------- (5)
LT660916,000726-Q---M---- (16)131,580,000250-Q---M---- (15)
LT742101,100754-----M---- (20)17800682-----M---- (20)
LT839111,800500---------- (20)197,790700---------- (8)
--------H- (8)
--------T- (3)
-----M---- (1)
LT94010200882-----M---- (5)17869430-----M---- (5)
LT103682005618200561-----M---- (4)
LT1136101,1001170101,1001170---------- (1)
--------H- (5)
LT12291014,600840-----M---- (4)16501131-----M---- (5)
LT1347124,000360-G-------- (5)19130,200340-G-------- (7)
LT1438161,190696161,190696-K---M---- (7)
LT1561117,000630-----M---- (4)114,400540-----M---- (4)
LT16391120092111200921---------- (4)
LT1739101,9001050-----M---- (20)172,300638-----M---- (18)
---T-M---- (2)
LT184089,200608---------- (6)148,920262---------- (8)
LT1944128,800814128,800814-K---M---- (5)
LT2033111461190NS
LT2139950910NS
  • Subjects generating escape variants at Gag codon 264 are shown in bold type. For LT10, LT11, LT14, L16, and LT19, only a single time point was available for evaluation.

  • a The number in parentheses indicates the number of clones with the reported sequence.

  • PID, patient identifier; NS, not able to be sequenced using standard sequencing.