Table I. Phenotype of gene-specific morphants
GeneOligonucleotide Sequencearag1/gh Ratiobp Valuecgh Area (a.u.)dp Valuec
None2.38 ± 0.13 (n = 22)1.000 ± 0.038
il7r5′-AGATAATCCACAAAAGTCCCGCCAT-3′1.17 ± 0.09 (n = 25)<0.0011.102 ± 0.0350.14
jak35′-ACGGCACCTCTTCCTCTTCACTCAT-3′1.55 ± 0.08 (n = 29)<0.0010.938 ± 0.0270.55
jak15′-TCCATGACTGCTAGTTCTGGCATCC-3′1.46 ± 0.20 (n = 11)<0.0010.905 ± 0.0430.32
  • a Antisense orientation.

  • b Mean ± SEM; the number of embryos (n) analyzed is shown in parentheses.

  • c Significance level relative to control; unequal variances t test, with Bonferroni correction for mutliple testing, two-tailed.

  • d Size of the hypophysis as determined by hybridization signal of gh gene is given in arbitrary units (a.u.); means ± SEM.