Table I. Comparison of human EE and IL-13–induced murine EE transcriptomes
Affy No.NO DOX versus DOXNL versus EESymbolGene Name
207328_at78.9721.27ALOX15Arachidonate 15-lipoxygenase
204470_at21.5817.41CXCL1Chemokine (C-X-C motif) ligand 1
206336_at3.5269.173CXCL6Chemokine (C-X-C motif) ligand 6
206529_x_at6.1258.25SLC26A4Solute carrier family 26, member 4
204580_at42.847.781MMP12Matrix metalloproteinase 12
207134_x_at1.3137.732TPSB2Tryptase β 2
209301_at4.0886.847CA2Carbonic anhydrase II
203854_at3.3466.522IFI factor (complement)
205579_at4.065.666HRH1Histamine receptor H1
206172_at5.4265.12IL13RA2IL 13R, α 2
205681_at6.33 246BCL2A1BCL2- related protein A1
207067_s_at5.763.141HDCHistidine decarboxylase
206134_at5.0732.853ADAMDEC1ADAM-like, decysin 1
223502_s_at7.9022.073TNFSF13BTNF superfamily, member 13b
209875_s_at9.5931.795SPP1Secreted phosphoprotein 1
205965_at10.181.456BATFBasic leucine zipper transcription factor, ATF-like
209800_at20.561.282KRT16Keratin 16
221698_s_at5.5221.257CLEC7AC-type lectin domain family 7, member A
209774_x_at7.8631.197CXCL2Chemokine (C-X-C motif) ligand 2
233534_at0.1880.187KRTAP3-2Keratin associated protein 3-2
  • Functional analysis of genes that have >5-fold changes in either the human or murine system revealed their involvement in cell communication, cytokine–cytokine receptor interaction, calcium signaling, histidine metabolism, complement and coagulation cascades, JAK-STAT signaling, and arachidonic acid metabolism. Those genes are among genes in the murine IL-13–induced esophageal transcriptome that overlapped with the human EE transcriptome (p < 0.05). DOX, mice treated with Dox for 4 wk; EE, biopsy samples from EE patients; NL, biopsy samples from non-EE patients; NO DOX, untreated mice.