Table II. Description of postmortem brain sections
Block No.SexAge (y)DD (y)Cause of DeathDFT (h)Sample TypeORO ScoreaSummary Observations on ORO-Stained Sections
1Female47Respiratory failure20NC W, FV, R0, 1All white matter
2Female68Colorectal metastatic tumor23NC W, OV, R0, 0All white matter
3Male49Myocardial infarction and coronary artery thrombosis11NC W, PV, R0, 0White matter with small edge of cortical gray matter
4Female4720Bronchopneumonia9MS AQ, OSv, L5, 2Large, very active MS plaque with white matter
5Female4720Bronchopneumonia9MS AQ, FSv, L4, 2Cortical gray matter surrounding subcortical normal-appearing white matter with an active lesion in center of section
6Female298Bronchopneumonia11MS acute and SAQs, CB, L3, 2Abnormal-appearing white matter with eight individual areas of acute or subacute plaque
7Male6921Multipleb14MS CQ, OV, R
WM0, 0
0, 2Chronic plaque along patchy white matter containing perivenular cuffing
8Female4622Bronchopneumonia8MS SAQ, CB, R2, 1Cerebellar gray and white matter with a large chronic plaque containing a small subacute area
9Female6034Renal failure24MS AQs, TV, L3, 4White matter, large chronic plaque, two active plaques and one subacute plaque; large perivenular cuffs
10Female4911Bronchopneumonia16MS SAQ, Pons1, 2Mostly chronic plaque with scattered ORO-positive macrophages; abnormal-appearing white matter
  • a ORO and cuffing: scored on a scale of 0–5 for ORO and hematoxylin staining; 0 is what would be expected in normal control white matter. Data are averaged from serial, duplicate sections cut immediately before and after the section examined by immunocytochemistry.

  • b 1A, myocardial infarction; 1B, pneumonia; 1C, diabetes mellitus; 2, MS.

  • –, not applicable; AQ, active plaque; CB, cerebellum; CQ, chronic plaque; DD, disease duration; DFT, death to snap-freezing time; F, frontal; L, left; NC W, normal control white matter; O, occipital; P, parietal; R, right; SAQ, subacute plaque; Sv, subventricular; T, temporal; V, ventricular; WM, white matter.