Table IV. Protection against an oral challenge of B. abortus 2308 in BALB/c mice orally immunized with U-Omp16 expressed in E. coli or in leaves of the tobacco species Nicotiana benthamiana
Vaccine (n = 5)Expressed inAdjuvantLog10 a CFU of B. abortus 2308 at Spleen (mean ± SD)Units of Protection
U-Omp16 E. coli None4.61 ± 0.17 b , c 0.94
U-Omp16TobaccoNone4.29 ± 0.08 b , d 1.26
B. abortus RB51None3.74 ± 0.44 b 1.81
PBSNone5.55 ± 0.05 c 0
  • a The content of bacteria in spleens is represented as the mean log10 CFU ± SD per group.

  • b Significantly different from PBS-immunized mice; p < 0.01 estimated by Dunnett’s test.

  • c Significantly different from B. abortus RB51 immunized mice; p < 0.01 estimated by Dunnett’s test.

  • d Significantly different from B. abortus RB51 immunized mice; p < 0.05 estimated by Dunnett’s test.