Table I. Metabolic comparisons between innate and adaptive immunity
Type of ImmunityInnateAdaptive
Cells involvedPMN, eosinophil Macrophage DCT cell, B cell, NK cell
Metabolic trigger(s)Recruitment DifferentiationLocal proliferation Recruitment
Activation stressor(s)Migration Phagocytosis Respiratory burstAg-induced differentiation
Metabolic adaptor(s)HIF, mTOR, AktHIF, mTOR, Akt
MitochondriaFewMany
Primary energy sourceGlycolysisRespiration
Methylation dependenceUnknownProliferation Ag-induced differentiation