Table I. Altered B cell subsets (%) in 8–12-mo-old B6.HELIg and B6.HELIg.sHEL mice with Sle2z
B6.HELIg (n = 5)B6.Sle2z/z.HELIg (n = 7)B6.HELIg.sHEL (n = 10)B6.Sle2z/z.HELIg.sHEL (n = 12)
IgMa+IgMb−83.1 ± 3.768.8 ± 4.4*61.8 ± 6.047.5 ± 3.6*
 FO-B (CD21intCD23hi)55.0 ± 2.943.4 ± 3.1*32.3 ± 2.121.8 ± 3.3**
 MZ-B (CD21hiCD23lo)20.9 ± 3.128.1 ± 4.010.3 ± 1.514.6 ± 1.6*
 B1a (B220loCD5+)1.2 ± 0.24.1 ± 1.2**1.7 ± 0.24.0 ± 1.1**
 λ LC+1.6 ± 0.15.6 ± 0.3***5.4 ± 0.78.9 ± 2.3
IgMa+IgMb+3.4 ± 0.68.6 ± 1.72.0 ± 0.22.7 ± 0.5
 FO-B (CD21intCD23hi)44.4 ± 7.630.2 ± 5.9*34.3 ± 5.438.5 ± 5.0
 MZ-B (CD21hiCD23lo)28.3 ± 5.048.6 ± 6.961.8 ± 6.455.0 ± 5.7
 B1a (B220loCD5+)1.3 ± 0.110.1 ± 1.5***2.3 ± 0.59.4 ± 1.2***
 λ LC+16.5 ± 0.317.3 ± 0.529.5 ± 3.830.1 ± 11.8
IgMa−IgMb+6.2 ± 1.221.9 ± 5.9*28.4 ± 5.543.0 ± 3.7*
 FO-B (CD21intCD23hi)47.5 ± 14.728.3 ± 6.135.0 ± 8.334.7 ± 5.3
 MZ-B (CD21hiCD23lo)24.9 ± 8.925.4 ± 6.736.4 ± 5.840.1 ± 6.4
 B1a (B220loCD5+)0.5 ± 0.112.1 ± 2.5***0.6 ± 0.118.2 ± 2.1***
 λ LC+15.7 ± 1.725.1 ± 1.8**21.9 ± 2.228.2 ± 0.5*
  • * p < 0.05, **p < 0.01, ***p < 0.0001, Student t test, B6.Sle2z/z.HELIg group versus B6.HELIg group or B6.Sle2z/z.HELIg.sHEL group versus B6.HELIg.sHEL group.