Table III. Comparison of different studies demonstrating survival and remission rates after treatment of established lupus nephritis in NZB/W F1 mice

	Median Survival in Weeks (Median Time to Death after Onset of Proteinuria in Weeks)
	Grade 3+	Grade 4+	Grade 3+ and 4+	Remission of Proteinuria Grade 3+ (4+) (%)	Median Time to Relapse Grade 3+ (4+) in Weeks
CTX (11)	—	—	—	10^a	—
Azathioprine (12)	—	—	—	18^a	—
CTX + azathioprine +  methylprednisolone (14)	—	—	44	0	—
C-reactive protein (16)	—	46	—	100	—
CTX + CTLA4Ig and CTX + CTLA4Ig + α-CD154 (15)	—	—	—	60–80^b^,^c	—
Irinotecan	70 (35)	76 (39)	73 (35)	75 (55)^b^,^c	9 (12)

↵^a Grade of proteinuria before treatment not indicated, for CTX alone at least 5 animals with grade 2+.
↵^b Defined as 30 mg/dl of proteinuria or less maintained for at least 3 wk.
↵^c Rate of remission owing to the first treatment cycle.