Table II. Dynamics of T cells and viral load in peripheral blood of HIV-1–infected mice with established infection with and without CD8+ cell depletion
CD8 (%)aCD4 (%)VL (Copies/ml)VL (log10)
Mouse No.BeforeAfterBeforeAfterΔ (%)BeforeAfterBeforeAfterΔ
CD8+ cell depleted animalsb1041.204.90.5−89.8114,800454,5005.065.660.60
1085.6010.12.7−73.35,7401,239,0003.766.092.33
30411.40.925.612.3−51.9245,3501,225,0005.396.090.70
30533.2045.911.6−74.78,435,00031,395,0006.937.500.57
Nondepleted animalsc3482.2nd5.2nd187,25075,2505.274.88−0.40
30210.77.252.413.3−74.68,050,000990,5006.916.00−0.91
1694.421.97.44.1−45.0205,450455,0005.315.660.35
14925.217.415.21.0−93.42,961,00062,6506.474.80−1.67
15935.719.112.77.7−39.4409,50038,1505.614.58−1.03
pd0.50.0140.4430.3430.2780.0320.4380.0160.008
  • a Percentage of human cells in peripheral blood at the time of viral load analysis.

  • b Mice were analyzed at 5–7 wk postinfection before CD8+ cell depletion and 2 wk after depletion.

  • c Data from nondepleted mice represent the first detected peak of viremia (before) and 2 wk after.

  • d p Values were determined by Mann-Whitney U test.

  • nd, no data.