Table II. Dynamics of T cells and viral load in peripheral blood of HIV-1–infected mice with established infection with and without CD8⁺ cell depletion

		CD8 (%)^{^a}		CD4 (%)			VL (Copies/ml)		VL (log₁₀)
	Mouse No.	Before	After	Before	After	Δ (%)	Before	After	Before	After	Δ
CD8⁺ cell depleted animals^{^b}	104	1.2	0	4.9	0.5	−89.8	114,800	454,500	5.06	5.66	0.60
	108	5.6	0	10.1	2.7	−73.3	5,740	1,239,000	3.76	6.09	2.33
	304	11.4	0.9	25.6	12.3	−51.9	245,350	1,225,000	5.39	6.09	0.70
	305	33.2	0	45.9	11.6	−74.7	8,435,000	31,395,000	6.93	7.50	0.57
Nondepleted animals^{^c}	348	2.2	nd	5.2	nd		187,250	75,250	5.27	4.88	−0.40
	302	10.7	7.2	52.4	13.3	−74.6	8,050,000	990,500	6.91	6.00	−0.91
	169	4.4	21.9	7.4	4.1	−45.0	205,450	455,000	5.31	5.66	0.35
	149	25.2	17.4	15.2	1.0	−93.4	2,961,000	62,650	6.47	4.80	−1.67
	159	35.7	19.1	12.7	7.7	−39.4	409,500	38,150	5.61	4.58	−1.03
p^{^d}		0.5	0.014	0.443	0.343		0.278	0.032	0.438	0.016	0.008

↵^a Percentage of human cells in peripheral blood at the time of viral load analysis.
↵^b Mice were analyzed at 5–7 wk postinfection before CD8⁺ cell depletion and 2 wk after depletion.
↵^c Data from nondepleted mice represent the first detected peak of viremia (before) and 2 wk after.
↵^d p Values were determined by Mann-Whitney U test.
nd, no data.