Table I. Dissemination of M. tuberculosis to the lung-draining LNs
5 d p.i.7 d p.i.9 d p.i.11 d p.i.
% LNs positive for CFUCtrl06089100
STZc03389100
Mean CFUCtrl01431180
STZc00171520
Range CFUCtrlna1–66–196*230–384
STZcna2–41–85281–2150
nCtrl111099
STZc9995
  • Nondiabetic (Ctrl) mice and mice with ≥3 mo STZc were infected with ∼100 CFU M. tuberculosis Erdman by aerosol and then lung-associated LNs were harvested for plating and colony counting on the indicated days p.i.

  • *p < 0.05 (one-tailed t test).

  • na, not available.