Table I.

mRNA transcription of cytokines/molecules after silencing either mBD2 or mBD3 or both (at 5 days p.i.)

Control siRNAmBD2 and mBD3 siRNApControl siRNAmBD2 siRNApControl siRNAmBD3 siRNAp
IFN-γ1.05 ± 0.145.38 ± 1.270.010.75 ± 0.292.22 ± 0.420.013.05 ± 0.276.27 ± 1.290.02
MIP-20.29 ± 0.040.58 ± 0.090.010.35 ± 0.070.75 ± 0.110.010.31 ± 0.060.55 ± 0.070.03
TNF-α0.26 ± 0.040.72 ± 0.170.010.39 ± 0.111.04 ± 0.12<0.010.43 ± 0.050.74 ± 0.100.01
IL-1β0.63 ± 0.101.24 ± 0.03<0.0010.62 ± 0.100.97 ± 0.050.010.79 ± 0.041.16 ± 0.110.01
iNOS1.25 ± 0.280.52 ± 0.070.020.25 ± 0.051.09 ± 0.09<0.0011.08 ± 0.080.64 ± 0.04<0.001
TLR40.73 ± 0.111.43 ± 0.120.0011.03 ± 0.161.63 ± 0.140.011.02 ± 0.021.23 ± 0.090.04
TLR20.75 ± 0.161.54 ± 0.160.010.65 ± 0.121.18 ± 0.120.010.84 ± 0.041.16 ± 0.140.04
MyD881.23 ± 0.172.68 ± 0.15<0.0011.24 ± 0.121.96 ± 0.15<0.0011.78 ± 0.072.06 ± 0.02<0.01
NF-kB0.73 ± 0.091.41 ± 0.07<0.0010.65 ± 0.071.00 ± 0.060.0010.65 ± 0.030.77 ± 0.040.03
TLR51.99 ± 0.272.4 ± 0.290.322.73 ± 0.282.21 ± 0.270.22.28 ± 0.122.08 ± 0.160.34
TLR91.24 ± 0.111.44 ± 0.120.331.33 ± 0.221.66 ± 0.120.321.83 ± 0.131.89 ± 0.190.76