Table I.

Percentages of NK cell subsets expressing self-MHC class I-specific inhibitory receptors in B6 micea

No PreactivationPoly(I:C) (preactivation)
ObservedbPredictedbObservedPredicted
C+I+NKG2+7.7 ± 0.6c9.0 ± 0.57.6 ± 1.08.6 ± 1.5
C+I+NKG211.1 ± 0.612.0 ± 0.79.2 ± 1.69.6 ± 1.5
CI+NKG2+17.4 ± 1.015.0 ± 1.018.4 ± 2.417.5 ± 1.8
C+INKG2+6.5 ± 0.67.1 ± 0.56.7 ± 1.26.8 ± 0.8
CI+NKG217.4 ± 1.020.0 ± 0.920.2 ± 1.119.7 ± 1.3
C+INKG212.1 ± 0.89.4 ± 0.89.1 ± 1.37.7 ± 1.1
CINKG2+11.2 ± 0.711.8 ± 0.614.3 ± 2.514.1 ± 1.8
CINKG215.7 ± 0.814.2 ± 0.914.5 ± 2.516.0 ± 2.7
  • a NK cells expressing any combinations of two or three self-MHC class I-specific inhibitory receptors in spleens from B6 mice previously treated or not with poly(I:C).

  • b Observed percentages are compared to those predicted by the product rule, which predicts percentages of cells expressing a combination of receptors by multiplying the percentages of cells expressing or not each receptor. For example, the predicted percentage of C+INKG2+ cells equals (%C+)(%I)(%NKG2+)/10,000.

  • c Numbers represent percentages of NKp46+ NK cells (mean ± SD; n = 5).