Table II.

Frequencies of anti-MAGE-3.A1 and anti-MAGE-C2.B44 CD8 T cells and anti-MAGE-3.DP4 CD4 T cells measured in tumor samples (cutaneous in transit metastases)a

200220032004
OctoberDecemberJanuaryAprilJuneOctoberNovemberDecemberFebruaryJuneAugust
CD8 anti-MAGE-3.A1 (clonotype 1)
 β-chain clonotypic PCR3.3 × 10−6<1.4 × 10−5 (7 × 104)1.5 × 10−5 (7 × 104)6.7 × 10−5 (7 × 104)
(3 × 105)
CD8 anti-MAGE-C2.B44 (clonotype A)
 β-chain clonotypic PCR(i) or TCRβ screening(ii)6.2 × 10−6 (i)1.5% (ii) (400)0.7% (ii) (151)2.2% (ii) (387)
(3 × 105)
CD4 anti-MAGE-3.DP4 (clonotype 2)
 β-chain clonotypic PCR<1.2 × 10−5<1.2 × 10−5 (8 × 104)1.4 × 10−5 (7 × 104)
(8 × 104)
  • a Values correspond to frequency among TCR β-chains. The number of TCR β-chains analyzed to establish the frequencies is represented in parentheses.