Table III.

Effect of 1,25(OH)2D3 on cell cycle regulatory gene expression

mRNAMean of Fold Changep Value
Cyclin-dependent kinase 60.830.12
Cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)0.990.43
Cyclin-dependent kinase 80.790.13
Cyclin-dependent kinase inhibitor 1A (p21, Cip1)0.740.08
Cyclin-dependent kinase inhibitor 1B (p27, Kip1)2.440.03
Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)1.650.38
Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.600.11
Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)0.960.35
CHK1 checkpoint homolog (Schizosaccharomyces pombe)0.720.19
CHK2 checkpoint homolog (S. pombe)0.830.17
CDC28 protein kinase regulatory subunit 1B0.760.08
CDC28 protein kinase regulatory subunit 20.860.04
Cullin 10.980.36
Cullin 20.740.14
Cullin 30.710.10
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, Saccharomyces cerevisiae)1.130.23
Dynamin 21.130.31
E2F transcription factor 4, p107/p130 binding0.820.23
Growth arrest and DNA-damage inducible, α1.850.22
General transcription factor IIH, polypeptide 1, 62 kDa0.960.26
G2 and S phase expressed 10.930.15
Hect domain and RLD 50.840.13
HUS1 checkpoint homolog (S. pombe)0.850.18
Kinetochore associated 10.790.01
Karyopherin α2 (RAG cohort 1, importin α1)0.740.05
MAD2 mitotic arrest deficient-like 1 (yeast)0.920.27
MAD2 mitotic arrest deficient-like 2 (yeast)0.810.05
MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)0.900.14
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)1.190.42
MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)0.790.13
MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)1.210.32
Antigen identified by monoclonal antibody Ki-670.650.04
Ménage-à-trois 1 (CAK assembly factor)0.720.05
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.730.02
Proliferating cell nuclear antigen0.830.09
RAD1 homolog (S. pombe)1.010.48
RAD17 homolog (S. pombe)1.070.12
RAD51 homolog (RecA homolog, Escherichia coli) (S. cerevisiae)1.560.22
RAD9 homolog A (S. pombe)0.960.44
Retinoblastoma 1 (including osteosarcoma)0.940.27
Retinoblastoma binding protein 80.850.14
Retinoblastoma-like 1 (p107)1.310.27
Retinoblastoma-like 2 (p130)0.970.37
Retinoblastoma protein A3, 14 kDa1.360.22
SERTA domain containing 11.350.18
S-phase kinase-associated protein 2 (p45)0.700.18
SMT3 suppressor of mif two 3 homolog 1 (yeast)0.720.02
Transcription factor Dp-10.850.11
Transcription factor Dp-2 (E2F dimerization partner 2)0.910.26
Tumor protein p53 (Li-Fraumeni syndrome)0.970.37
Ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing)2.860.21