Table III.

Gene profile in Syncytin-1-expressing astrocytes showing up-regulation and down-regulation of immune response, myelin-related, and ER stress genes

Gene NameFunctionFold ChangeGenBank ID
ER stress response
STCHStress 70 protein chaperone, microsome-associated, 60 kDa8.3AI718418
HSPH1Heat shock 105-kDa/110-kDa protein 15.285714NM_006644
LONPPeroxisomal lon protease3.32AV700132
FLJ23560Hypothetical protein FLJ235602.564103NM_024685
FLJ14281Hypothetical protein FLJ142812.375NM_024920
HSPD1Heat shock 60-kDa protein 1 (chaperonin)2.236842NM_002156
SERP1Stress-associated endoplasmic reticulum protein 12.261905AL136807
HERPUD1Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 10.735294BC015447
HSPA5BP1Heat shock 70-kDa protein 5 (glucose-regulated protein, 78 kDa) binding protein 10.710692AB046803
GADD45BGrowth arrest and DNA-damage-inducible, β0.702899AV658684
Syncytin-1HERV-W envelope glycoprotein3.114286AC000064
SLC1A4 (ASCT1)Solute carrier family 1 (glutamate/neutral amino acid transporter), member 40.677632W72527
SLC1A5 (ASCT2)Solute carrier family 1 (neutral amino acid transporter), member 50.693431AF105230
MS related
ADAM10A disintegrin and metalloproteinase domain 108.25N51370
MS lesionMS lesion transcript6.818182N73682
CMT4B2Charcot-Marie-Tooth neuropathy 4B2 (autosomal recessive, with myelin outfolding)4.478261AK022478
MBPMyelin basic protein0.734266NM_002385
MAGMyelin-associated glycoprotein0.685039X98405
Immune response
SOCS5Suppressor of cytokine signaling 55.375NM_014011
STAT1Signal transducer and activator of transcription 1, 91 kDa2.121951NM_007315
TLR4Toll-like receptor 42.05NM_003266
TLR9Toll-like receptor 90.731707AB045180
IL23AInterleukin 23, α subunit p190.724138NM_016584
OLIG1Oligodendrocyte transcription factor 10.722222AL355743
TLR8Toll-like receptor 80.606838NM_016610
OAS12′,5′-oligoadenylate synthetase 1, 40/46 kDa0.413408NM_002534