Table II.

Genes increased and decreased in Syncytin-1-expressing astrocytes, showing a similar profile in lesions from MS patients

Gene NameFunctionFold ChangeGenBank ID
IncreasedCEBPGCCAAT/enhancer-binding protein (C/EBP), γ2.75BE622659
TNFRSF6Tumor necrosis factor receptor superfamily, member 62.433333NM_000043
RCN1Reticulocalbin 1, EF-hand calcium-binding domain1.607143NM_002901
DecreasedGAD2Glutamate decarboxylase 2 (pancreatic islets and brain, 65 kDa)0.961538BQ128302
SPOCK2Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 20.955752NM_014767
SSTSomatostatin0.913462NM_001048
NEUROD2Neurogenic differentiation 20.875AB021742
PVALBParvalbumin0.869565NM_002854
CCNICyclin I0.854701BG530368
SCDStearoyl-CoA desaturase (δ-9-desaturase)0.842105BC005807
RPS4Y1Ribosomal protein S4, Y-linked 10.827586NM_001008
RAB5BRAB5B, member RAS oncogene family0.820896AF267863
PEG3Paternally expressed 30.817308AF208967
HTR75-Hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)0.706767NM_019859
ACAT2Acetyl-coenzyme A acetyltransferase 2 (acetoacetyl coenzyme A thiolase)0.704403BC000408
HSPA6Heat shock 70-kDa protein 6 (HSP70B′)0.7NM_002155
AQP11Aquaporin 110.680272AI886656
MAP1DMethionine aminopeptidase 1D0.675676AA779679
KIF5AKinesin family member 5A0.666667AF063608
CNP2′,3′-Cyclic nucleotide 3′ phosphodiesterase0.619792AK098048
EXTL3Exostoses (multiple)-like30.619355BC006363