Table II.

Skin transplant histological score with H&E staina

Epidermal ThicknessDegree of Inflammation
Vehicle0.71 ± 0.143.71 ± 0.71
ATL3131.57 ± 0.17c1.57 ± 0.6b
ATL313 + ZM0.81 ± 0.13e3.5 ± 0.60d
  • a Sections were examined at the end of the experimental period (day 9) in a masked fashion under ×400 magnification by light microscopy. The assessment was based on the thickness of the donor epidermis (0–2 score) with 0 = loss of epidermal thickness and 2 = full epidermal thickness, and the degree of inflammation (0–5 score) with 0 = no inflammation and 5 = severe inflammation. Values represent mean ± SEM (

  • b p < 0.05, and

  • c p < 0.001 to vehicle;

  • d p < 0.05, and

  • e p < 0.005 to ATL313 alone). n = 8/group.