Table I.

Microscopic changes in CNS of WT, p19KO, p35KO, and p35/p19DKO mice adoptively transferred with WT encephalitogenic cells

GroupBrainSpinal Cord
CervicalThoracicLumbar
Incidence (%)aMean no. of focibIncidence (%)Mean no. of fociIncidence (%)Mean no. of fociIncidence (%)Mean no. of foci
WT7/7 (100)c16.0 ± 3.07/7 (100)4.6 ± 0.67/7 (100)2.3 ± 0.47/7 (100)2.1 ± 0.5
p19KO7/7 (100)c10.6 ± 1.27/7 (100)2.9 ± 0.4d7/7 (100)1.3 ± 0.4d7/7 (100)1.8 ± 0.2
p35KO7/7 (100)c12.4 ± 4.57/7 (100)2.4 ± 0.2e7/7 (100)1.8 ± 0.37/7 (100)1.4 ± 0.4
p35/p19DKO7/7 (100)c10.1 ± 2.47/7 (100)3.5 ± 0.67/7 (100)1.9 ± 0.37/7 (100)2.6 ± 0.4
  • a Mice with any inflammatory cell infiltrates were considered positive.

  • b Mean number of foci of 20 or more inflammatory cells ± SEM.

  • c Number of mice affected per number of mice examined (percent affected).

  • d p < 0.05 compared with WT.

  • e p < 0.005 compared with WT.