Table I.

Comparative frequencies of CD4+CD25+, CD4+CD25high, and FOXP3+ cells and sex hormone levels during the menstrual cycle

Day 3aDay 9Day 12aDay 19Day 24
First menstrual cycle
 Absolute number CD4+/μlb900.0974.01150.01102.0957.0
 CD4+CD25+ frequency, %c13.
 CD4+CD25high frequency, %d0.971.
 FOXP3 expression, %e3.
 Estradiol level, pg/ml30.0146.0219.0106.031.0
 Progesterone level, ng/ml0.250.200.8911.700.43
Second menstrual cycle
 Absolute number CD4+/μlb953.0870.0910.0890.0960.0
 CD4+CD25+ frequency, %c9.911.
 CD4+CD25high frequency, %d0.780.861.120.951.27
 FOXP3 expression, %e2.
 Estradiol level, pg/ml31.074.0173.082.0118.0
 Progesterone level, ng/ml0.200.200.2212.313.90
  • a Days of the menstrual cycle.

  • b Absolute count of CD4+ cells acquired from complete blood.

  • c Frequency of peripheral blood CD4+CD25+ T lymphocytes expressed as percentage of CD4+ T lymphocytes.

  • d Frequency of peripheral blood CD4+CD25high T cell subset expressed as percentage of CD4+ T lymphocytes.

  • e Frequency of FOXP3 expression in peripheral blood CD4+ T lymphocytes.