Table I.

CD5 expression is increased on CD8+ OVA-specific T cells in 11c.OVA micea

Nontransgenic11c.OVA11c.OVA/Anti-CD40
167314 (1.9)147 (0.9)
92392 (4.3)230 (2.5)
44113 (2.6)36 (0.8)
70215 (3.1)35 (0.5)
MFI (mean ± SD)93 ± 53259 ± 121b92 ± 85
Fold increasec (mean ± SD)3.0 ± 1.0d1.2 ± 0.9
  • a Spleens were harvested from recipients of CD45.1+ OT-I and CD45.1+ OT-II T cells 21 days after transfer and the expression of CD5 was determined by flow cytometry. Data were collected from histograms gated on CD45.1+CD8+ (OT-I) cells and pooled from two separate experiments each with two mice per group.

  • b Significantly greater than 11c.OVA plus anti-CD40 (p < 0.01).

  • c Relative to cells transferred to nontransgenic controls.

  • d Significantly greater than 11c.OVA plus anti-CD40 (p < 0.05).