Table I.

Less accumulation of peripheral T cells in young TNF−/− micea

% CD4CD4+ (×106)% CD8CD8+ (×106)
C57BL/10 17 day (n = 11)12.0 ± 1.378.22 ± 2.26b5.95 ± 0.853.73 ± 1.05c
TNF−/− 17 day (n = 15)8.50 ± 1.484.25 ± 0.74b4.25 ± 0.102.13 ± 0.48c
C57BL/10 adult (n = 5)25.4 ± 3.6139.9 ± 7.4914.3 ± 1.8420.1 ± 5.60
TNF−/− adult (n = 4)24.8 ± 4.3436.0 ± 6.6013.11 ± 1.5618.00 ± 2.32
  • a Seventeen-day-old C57BL/10 or TNF−/− mice were sacrificed and absolute numbers of CD4+ and CD8+ splenocytes were determined by flow cytometry. Results represent a collection of three independent experiments. For comparison, average numbers from C57BL/10 and TNF−/− adult mice are shown (all p values between adult C57BL/10 and TNF−/− adults were >0.38).

  • b Value of p < 3 × 10−5.

  • c Value of p < 2 × 10−4.