Table II.

Regions of linkage to cell distribution in (B10.Q × NOD.Q) × B10.Q backcrossa

PhenotypesLocusMarkerPosition (cM)bPosition (Mb)cLOD Scored
B cell:T cell ratio (B220/CD3)D12Mit7643.082.62.88e
B cells (B220)D12Mit7643.082.64.41g
T cells (CD3)D1Mit8963.1124.43.08e
D13Mit7875.0115.83.15e
CD4:CD8 ratioD8mit18034.074.04.60g
D12Mit7643.082.64.96g
D14Mit110.78.73.16f
CD8D2mit9850.398.62.69e
CD11bCia2D2mit29618.031.33.25f
D4Mit412.137.03.08e
D7Mit24615.022.03.43f
D10Mit8617.024.35.11g
  • a QTL analysis was performed using R/qtl (30). Significance levels were established by permutation. Frequency distribution of cells in serum was determined by flow cytometry. Arthritis severity was expressed as maximal arthritic score and as accumulated arthritic scores along the time course of the experiment.

  • b Genetic position according to Mouse Genome Informatics (〈http://www.informatics.jax.org/〉).

  • c Physical position according to Ensembl Mouse Genome Server (〈http://www.ensembl.org/Mus_musculus/〉).

  • d LOD score calculated allowing gender as interactive covariate using R/qtl (〈http://www.biostat.jhsph.edu/≈kbroman/qtl/〉). Significance levels:

  • e , p (0.90);

  • f , p (0.95);

  • g , p (0.99).