Table I.

Regions of linkage to arthritis incidence and severity identified in (B10.Q × NOD.Q) × B10.Q backcrossa

Arthritis PhenotypesLocusMarkerPosition (cM)bPosition (Mb)cLOD Scored
IncidenceCia9D1mit34981.6158.52.77e
Cia2D2mit296-D2Mit9118.0–37.031.1–66.74.25g
Maximum scoreCia9D1mit34981.6158.56.35g
Cia2D2mit29618.031.38.62g
D10Mit507.02.94e
Accumulated arthritis scoreCia9D1mit34981.6158.55.90g
Cia2D2mit296-D2Mit9118.0–37.031.1–66.75.82g
D10Mit507.017.52.54e
  • a QTL analysis was performed using R/qtl (30). Significance levels were established by permutation. Arthritis severity was expressed as maximal arthritic score and as accumulated arthritic scores along the time course of the experiment.

  • b Genetic position according to Mouse Genome Informatics (〈http://www.informatics.jax.org/〉).

  • c Physical position according to Ensembl Mouse Genome Server (〈http://www.ensembl.org/Mus_musculus/〉).

  • d LOD score calculated allowing gender as an interactive covariate using R/qtl (〈http://www.biostat.jhsph.edu/≈kbroman/qtl/〉). Significance levels:

  • e , p (0.90);

  • f , p (0.95);

  • g , p (0.99).