Table II.

Analysis of chemokine receptor expression on NK cell lines by migration assay and FACS

NKL MigrationFACSKHYG-1 MigrationFACSNK-92 MigrationFlow Cytometry
CD56−/dim+Bright
CD16+
CCR1+ (CKβ8; EC50 410 pM)+
CCR2
CCR3ND
CCR4+ (MDC; EC50 5 pM)+
CCR5
CCR6+ (MIP-3α; EC50 120 pM)+
CCR7+ (MIP-3β; EC50 3 nM)++/− (MIP-3β; EC50 12 nM)
CCR8
CCR9
CCR10NDNDND
CXCR1
CXCR2
CXCR3++ (I-TAC; EC50 110 pM)++ (I-TAC; EC50 6 pM)+
CXCR4+ (SDF-1α; EC50 4 pM)++ (SDF-1α; EC50 2 nM)++ (SDF-1α; EC50 3 nM)+
CXCR5
CXCR6
CX3CR1+ (FK-CK; EC50 50 nM)NDND+/− (FK-CK; EC50 > 150 nM)ND