Table I.

Summary of phenotypic characteristics of F11/12(DBA/1J × FVB/N) AILa

Total MiceFemalesMales
Incidence***33.4%20.6%44.2%
Severity6.6 ± 12.34.3 ± 10.58.5 ± 13.4
Severity†19.4 ± 14.120.1 ± 14.619.1 ± 14.1
Onset score10.8 ± 16.57.2 ± 15.013.7 ± 17.1
Onset score†31.9 ± 11.134.9 ± 10.930.9 ± 11.1
AUC49.6 ± 103.631.5 ± 84.663.8 ± 114.7
AUC†123.5 ± 133.9114.3 ± 132.5126.9 ± 135.2
IgG2a0.92 ± 0.330.92 ± 0.340.91 ± 0.32
CD4:CD8**1.27 ± 0.381.39 ± 0.411.18 ± 0.34
  • a IgG2a, Anti-bovine collagen II IgG2a Ab. CD4:CD8, CD4:CD8 T cell ratio in LN. Data are presented as mean ± SD. †, Phenotypes are calculated from diseased mice. Asterisks indicate significance of sex effect on phenotypes: ∗∗, p < 0.01; ∗∗∗, p < 0.001.