Table I.

Activation of lung αE-DC in mice with asthma-like diseasea

Surface AgRelative Mean Fluorescence Intensity
ControlOVA-immunized
B7–1 (CD80)2.3 ± 0.62.9 ± 0.7
B7–2 (CD86)5.7 ± 1.4 16.1 ± 6.2
B7-H1 (PD-L1)2.4 ± 0.82.8 ± 0.1
B7-DC (PD-L2)1.7 ± 1.1 3.9 ± 0.6
ICOS-L3.8 ± 0.42.0 ± 0.8
CD401.6 ± 0.3 32.4 ± 18
ICAM-1 (CD54)62.4 ± 13.4216 ± 102
CD49d8.4 ± 2.3 18.9 ± 9.8
CD49e22.9 ± 8.616 ± 6.2
CD514.7 ± 2.03.0 ± 0.3
CD611.7 ± 0.3 5.9 ± 1.1
I-A110 ± 9.3273 ± 162
TLR26.4 ± 0.97.6 ± 1.7
  • a Purified lung DC were stained by mAb against CD11c, CD103, and the indicated markers and gated on the CD11c+CD103+ population for activation analysis. The results are the average of four experiments. Data were normalized against isotype control and expressed as mean ± SD. Bold indicates statistical significance (p < 0.05).