Table IV.

Gene expression modulation during L. casei time coursea

GO Biological ProcessbProbe SetRefSeq IDGene NameModulationcFold Changed
Group 1: Cell growth/cell cycle201278_atNM_001343Disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)D−4.68
201202_atNM_002592Proliferating cell nuclear antigenD−4.29
216237_s_atNM_006739MCM5 minichromosome maintenance deficient 5, cell division cycle 46D−4.07
203625_x_atNM_005983S-phase kinase-associated protein 2 (p45)D−3.93
204318_s_atNM_016426G-2 and S-phase expressed 1D−3.42
204709_s_atNM_004856Kinesin family member 23D−3.14
200659_s_atNM_002634ProhibitinD−3.08
209662_atNM_004365Centrin, EF-hand protein, 3 (CDC3 1 homolog, yeast)D−2.98
204162_atNM_006101Kinetochore associated 2D−2.88
214710_s_atNM_031966Cyclin B1D−2.83
207165_atNM_012484Hyaluronan-mediated motility receptor (RHAMM)D−2.73
202883_s_atNM_002716Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), βD−2.73
208712_atNM_001758Cyclin D1 (PRAD1: parathyroid adenomatosis 1)D−2.51
213222_atNM_015192Phospholipase C, β 1 (phosphoinositide-specific)D−2.51
203145_atNM_006461Sperm associated antigen 5D−2.46
204444_atNM_004523Kinesin family member 11D−2.46
202240_atNM_005030Polo-like kinase 1 (Drosophila)D−2.42
200959_atNM_004960fusion (involved in t(12;16) in malignant liposarcoma)D−2.38
218350_s_atNM_015895geminin, DNA replication inhibitorD−2.34
203078_atNM_003591Cullin 2D−2.30
203362_s_atNM_002358MAD2 mitotic arrest deficient-like 1 (yeast)D−2.22
212426_s_atNM_006826Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activationD−2.22
212949_atNM_015341Barren homolog (Drosophila)D−2.18
208727_s_atNM_001791cell division cycle 42 (GTP binding protein, 25 kDa)D−2.18
201938_atNM_004642CDK2-associated protein 1D−2.14
203740_atNM_005792M-phase phosphoprotein 6D−2.03
201664_atNM_0012799SMC4 structural maintenance of chromosomes 4-like 1 (yeast)D−1.90
218009_s_atNM_003981Protein regulator of cytokinesis 1D−1.90
201725_atNM_006023Chromosome 10 open reading frame 7D−1.87
220789_s_atNM_004749Transforming growth factor β regulator 4D−1.87
204817_atNM_012291Extra spindle poles like 1 (S. cerevisiae)D−1.87
201186_atNM_002337Low-density lipoprotein receptor-related protein associated protein 1D−1.65
221509_atNM_003677Density-regulated proteinD−1.57
201173_x_atNM_006600Nuclear distribution gene C homolog (A. nidulans)D−1.46
217839_atNM_006070TRK-fused geneI1.87
219910_atNM_007076Huntingtin interacting protein EI2.38
203226_s_atNM_005981Sarcoma amplified sequenceI2.55
202205_atNM_003370Vasodilator-stimulated phosphoproteinI3.86
202061_s_atNM_005065sel-1 suppressor of lin-12-like (C. elegans)I3.86
210513_s_atNM_003376Vascular endothelial growth factorI4.07
205569_atNM_014398Lysosomal-associated membrane protein 3I4.92
200598_s_atNM_003299Tumor rejection antigen (gp96) 1I5.46
Group 2: Apoptosis220643_s_atNM_018147Fas apoptotic inhibitory moleculeD−5.10
221690_s_atNM_017852NACHT, leucine rich repeat and PYD containing 2 (Nalp2)D−4.68
202268_s_atNM_003905Amyloid β precursor protein binding protein 1, 59 KDaD−2.14
220044_x_atNM_006107Cisplatin resistance-associated overexpressed proteinD−2.14
208424_s_atNM_020313Cytokine induced apoptosis inhibitor 1D−2.11
219275_atNM_004708Programmed cell death 5D−1.65
203489_atNM_006427CD27-binding (Siva) proteinD−1.49
221479_s_atNM_004331BCL2/adenovirus E1B 19 kDa interacting protein 3-likeI2.30
202731_atNM_014456Programmed cell death 4 (neoplastic transformation inhibitor)I3.36
202014_atNM_014330Protein phosphatase 1, regulatory (inhibitor) subunit 15AI7.21
Group 3: Hypoxia200825_s_atNM_006389Hypoxia up-regulated 1I3.86
202887_s_atNM_019058HIF-1 response RTP801I4.92
Group 4: Ubiquitination/218117_atNM_014248Ring-box 1D−4.07
 degradation212751_atNM_003348Ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)D−2.88
201377_atNM_014847Ubiquitin associated protein 2-likeD−2.42
201498_atNM_003470Ubiquitin specific protease 7 (herpes virus-associated)D−2.34
211764_s_atNM_003338Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)D−2.22