Table I.

Deduced amino acid sequences of loops comprising CDRs of L-SIGN Fabs

CloneCDR1aCDR2aCDR3a
H chain sequences
 D12G Y N M NN I D P Y Y G D I T Y N Q K F K GT A T A L Y T M D
 C7b - - - - -- F - - - - - V - - - - - - - - -- - - - - - - - - -
 E4- - - - -- - - - - - G G S S - - - - - - -- - - - - - - - - -
 G10- - - - -- - - - - - - - - - - - - - - - -- - - - - - - - - -
 E10S - L - ST - S S G G S F T Y - P D N V - -E F - I - - K A L -
 G3T - G L HV - W R G G N - T D - - A A F M SN - D Y Y W G - F G
L chain sequences
 D12T A S S S V S S S Y L HS T S N Q A S GQ Q F T S S P S T
 C7R - - - - - - - - - - - - - -- - - - - - - -- - Y S G Y - L -
 E4R - - - - - - - - - - - - - -- - - - - - - -- - Y S G Y S L-
 G10R - - - - - - - - - - - - - -- - - - - - - -- - Y S G - - L -
 E10R - - E - - D - Y G N - F M -L A - - - E - -- - N N E D - Y -
 G3K - - Q D - G - - - - T A V AW - - T R H T -- - Y S - Y - F -
  • a Sequence positions of CDR1, 2 and 3 as described in (Ref.29 ).

  • b (-) Represents same residue as in clone D12.