Table I.

Effect of caspase-9 inhibition on established Pneumocystis infection in rats

ConditionaAlveolar Macrophages (×106)TUNEL-Positive Cells (%)Trophozoites/×1000 FieldCysts/×1000
Dex-Pc + PBS1.97 ± 0.239.6 ± 4.135.3 ± 2.64.5 ± 0.5
Dex-Pc + inhibitor-9 treated once3.46 ± 0.2b23.1 ± 0.8b9.2 ± 0.8b1.0 ± 0.2b
Dex-Pc + inhibitor-9 treated twice3.86 ± 0.3b14.3 ± 0.6bc4.9 ± 0.6bc0.3 ± 0.1bc
  • a Eight to 12 rats/condition.

  • b p < 0.05 vs PBS control.

  • c p < 0.05 vs once treated.