Table I.

Increased number of CD11b+ cells within CNS melanomas in animals treated with MAA peptide-pulsed DC vaccination and 5% Imiquimoda

GroupNo. Cells/0.25 mm2
Expt. no. 1 (average ± SEM)Expt. no. 2 (average ± SEM)
Control B16-Fluc tumor9.5 ± 1.9b11.6 ± 1.8b
5% Imiquimod B16-Fluc tumor45.5 ± 5.0c37.4 ± 3.1c
Positive control spleen127.7 ± 9.6131.2 ± 5.6
  • a Immunhistochemistry was performed for CD11b in two independent experiments. The number of positively labeled cells was counted using a grid in eight locations within the tumor or spleen (+ control). Magnification, ×200. Area of grid, 0.25 mm2.

  • b p < 0.0004, and

  • c p < 0.0005 (both control vs Imiquimod Tx using the paired t test).