Table IV.

Ig deposition and renal disease severity to VRT101-treated MRL/lpr/lpr micea

TreatmentRenal GNDeposition of Igs
IgAIgGIgM
PBSII+1+2
PBSIV+3+2+2
PBSII+1+2
PBSIII+1+2+2
VRT101II
VRT101II
VRT101II+2+2
VRT101II
VRT101II
VRT101II+1
VRT101II+2
  • a MRL/lpr/lpr mice were injected i.p. with 80 μg of VRT101 peptide or with PBS, five times weekly, for 260 days. Renal pathology and immune complex deposition were evaluated as described in Materials and Methods. Deposition of Igs: +1, mild; +2, moderate; and +3, severe. Renal GN: class II, mesangial proliferative GN; class III, focal proliferative GN; and class IV, diffuse proliferative GN.