Table II.

Anti-DNA and anti-VRT101 serum levels and renal pathology in congenic lupus micea

MiceAnti-VRT101 (OD 405 nm)Anti-DNA (cpm)Renal GN
c1 (Sle1)(n = 8)0.28 ± 0.04b1328 ± 167b
c4 (Sle2) (n = 8)0.32 ± 0.1713 ± 104
c7 (Sle3) (n = 8)0.24 ± 0.021482 ± 103
c1/c7 (Sle1/Sle3) (n = 6)0.4 ± 0.1c2540 ± 167c+1
c1/c4/c7 (Sle1/Sle2/Sle3) (n = 10)0.87 ± 0.14d2711 ± 167c+3
BALB/c (n = 8)0.13 ± 0.0473 ± 21ND
  • a Sera from congenic lupus mice (7–9 mo old; 1/100), carrying lupus-susceptibility genes, were tested for binding to VRT101 and DNA and their kidney pathology was expressed as follows: +3, severe diffuse GN; +2, moderate diffuse GN; +1, mild GN; +/−, borderline GN; and ND, not done.

  • b Mean ± SD.

  • c p < 0.02 compared to BALB/c, c1, c4, and c7 strains.

  • d p < 0.05 compared to BALB/c, c1, c4, c7, and c1/c7 strains.