Table III.

Effect of endogenous h-β2m on B6 lymphoblast sensitivity to Wt B6 Ly49C+ or Ly49C LAKa

Target Con ATarget TreatmentEffector Phenotype
Ly49C+ Wt LAKLy49C Wt LAK
Wt B63% MS3.8 ± 0.74.4 ± 1.3
Wt B63% MS; pOVA15.0 ± 1.55.6 ± 0.9
Wt B63% MS; α-Ly49C11.6 ± 0.73.7 ± 0.7
Wt B6h-β2m11.8 ± 0.911.5 ± 1.5
h-β2m B63% HS19.9 ± 1.819.3 ± 1.5
h-β2m B63% HuS; pOVA19.3 ± 0.718.6 ± 0.9
h-β2m3% HuS; α-Ly49C18.6 ± 1.517.5 ± 0.8
  • a Cells used as targets were from Wt B6 or h-β2m transgenic B6 mice and were cultured in MS or HS. Targets were prepulsed with pOVA or h-β2m or Ly49C recognition blockaded as indicated.