Table I.

Innate effects of human HSP60 on immune cellsa

EffectCell TypeReferences
MODCT cellsB cells
ProliferationNoNoNoYes
Cytokine secretionTNF-αTNF-αNDIL-1028 29 31
NOIL-12Low IL-6
IL-12IL-1β
IL-15Low IL-10
IL-6
Surface markersNDCD40↑CXCR4↓CD40↑8 28
MHC II↑CCR7↓MHC II↑
B7-2↑B7-2↑
CD54↑CD89↑
TLR dependencyTLR4TLR4TLR2TLR4 Except MHC II↑8 28 30 35
TLR2
MyD88 dependencyYesNDNDYes35
Other functionsActivationMaturationAdhesion↑IgG3 switch8 28 29
Migration↓
  • a DC, dendritic cell; MO, macrophage.