Table II.

Role of T cells in the development of CAV in parental to F1 transplants

GroupDonorRecipientTreatmentHearts with CAV
1C57BL/6.RAG1−/−CB6F1None5/5a
2C57BL/6.RAG1−/−CB6F1.RAG1−/−None0/9
3C57BL/6.RAG1−/−CB6F1.RAG1−/−CD4+ T cellsb3/5a
  • a p < 0.05 by Fisher’s exact test compared with group 2.

  • b Adoptive transfer of 5 × 106 wild-type CB6F1 CD4+ T cells on the day of transplant.