Table I.

Allograft vasculopathy in parental to F1 heart transplants

GroupDonorRecipientPalpation ScoreaStage of CAVbHearts with CAV
1C57BL/6(C57BL/6 × BALB/c)F12.82.319/22c
2C57BL/6(C57BL/6 × B10.D2)F13.01.53/4c
3C57BL/6(C57BL/6 × C3H/HeJ)F12.30.43/9
4C57BL/6C57BL/62.800/7
5(C57BL/6 × BALB/c)F1(C57BL/6 × BALB/c)F12.800/9
6(C57BL/6 × B10.D2)F1(C57BL/6 × B10.D2)F13.000/3
7C3H/HeJ(C57BL/6 × BALB/c)F1N/AN/AAcute rejection
  • N/A, Not applicable.

  • a Average group palpation score, graded from 0 to 3, determined at the time the mice were killed (day 56).

  • b Average group severity score, graded from 0 to 3, determined at the time the mice were killed (day 56).

  • c p < 0.05 by Fisher’s exact test compared with group 4.