Table I.

Plasma cytokine concentrations following CLPa

sTNFR1 (pg/ml)IL-1ra (pg/ml)IL-6 (pg/ml)IL-10 (pg/ml)IL-13 (pg/ml)IL-18 (pg/ml)IL-12 p70 (pg/ml)IFN-γ (pg/ml)MCP-1 (pg/ml)MIP-2 (pg/ml)
Sham, wild-type littermates + DT222 ± 1922684 ± 270559 ± 612 ± 0147 ± 21312 ± 012 ± 012 ± 0188 ± 7624 ± 0
Sham, DCKO mice + DT479 ± 2171854 ± 7411875 ± 259812 ± 083 ± 7167 ± 95c12 ± 012 ± 0291 ± 211225 ± 348
Wild-type littermates + DT following CLP999 ± 178b55089 ± 52935b15806 ± 7956b664 ± 830244 ± 23919 ± 1912 ± 0.872 ± 1581949 ± 1779b4818 ± 4258b
DCKO mice + DT following CLP1082 ± 356b31547 ± 27092b18181 ± 12607b365 ± 280328 ± 285267 ± 185c25 ± 2221 ± 181602 ± 1020b3027 ± 2403b
  • a Values represent the mean ± SD.

  • b , p < 0.05, CLP vs sham;

  • c , p < 0.05, DCKO vs wild-type littermates.