Table II.

Cytokine production from resident peritoneal macrophagesa

MediumThioglycollate
LysM:Stat3+/+LysM:Stat3flox/−LysM:Stat3+/+LysM:Stat3flox/−
TNF-α0.03 ± 0.010.26 ± 0.01c0.05 ± 0.010.52 ± 0.03c
MIP-22.8 ± 0.14.7 ± 0.2c4.1 ± 0.26.9 ± 0.3c
KC3.1 ± 0.16.5 ± 0.5c6.2 ± 0.511.6 ± 1.0b
MCP-10.8 ± 0.14.5 ± 0.5c4.5 ± 0.28.4 ± 1.2b
IL-100.23 ± 0.011.12 ± 0.03c0.56 ± 0.012.22 ± 0.52c
  • a Peritoneal resident macrophages were harvested from LysMcre/Stat3+/+ and LysMcre/Stat3flox/− mice, and the cells were stimulated with thioglycollate (0.4% v/v) for 24 h. The cytokine level in the supernatants was measured by ELISA (nanograms per milliliter, n = 6). Shown are representative data from three independent experiments.

  • b , p < 0.001,

  • c , p < 0.0001, vs LysMcre/Stat3+/+ macrophages.