Table I.

Rat and mouse cytokine and chemokine levelsa

Day 3Day 14Day 28
AM+AMAM+AMAM+AM
Fischer rat cytokine and chemokine levels
 IL-1β1,798 ± 2311,641 ± 4072,254 ± 8122,059 ± 7033,815 ± 3723,084 ± 257b
 IL-IRA7 ± 318 ± 8b78 ± 5111 ± 53391 ± 12463 ± 4b
 IL-1059 ± 623 ± 11b57 ± 995 ± 24b50 ± 1157 ± 6
 IFN-γndndndnd65 ± 1558 ± 10
 TNF-αndndndnd54 ± 1548 ± 8
 TGF-β128 ± 33127 ± 1492 ± 22115 ± 1496 ± 10114 ± 26
 MCP-114 ± 336 ± 7b21 ± 658 ± 8b48 ± 959 ± 9
 MIP-2216 ± 34369 ± 53b200 ± 49420 ± 55b367 ± 29333 ± 38
A/J mouse cytokine and chemokine levels
 IL-1β1,544 ± 4801,779 ± 3991,807 ± 5473,015 ± 1,028b
 IL-10695 ± 132664 ± 249916 ± 223517 ± 143b
 TNF-α255 ± 46334 ± 129602 ± 171353 ± 86b
 TGF-β9,642 ± 1,8694,362 ± 3,017b16,938 ± 7,92913,542 ± 3,704
 MCP-1172 ± 473,249 ± 2,620b173 ± 35350 ± 124b
  • a Cytokine/chemokine levels in nondepleted (AM+) and AM-depleted animals (AM). All cytokine and chemokine concentrations are given in picograms per milliliter, except rat IL-1RA and rat MCP-1 which are given in nanograms per milliliter.

  • b , p < 0.05 compared with control animals at the same time of infection. Arrows represent direction of change in value in association with AM depletion (n = 5–7 animals per group). nd refers to not detected, limit of detection for this assay was 32 pg/ml.