Table I.

Inhibitory effect (IC50, μM) of C3a and C3a-derived peptides on the IgE-mediated degranulation of RBL-2H3, BMMC, and RPMCa

RBL-2H3BMMCRPMC
C3ab2,40,2Activationb
C3a75269123
C3a95169105
Control peptideNo effectNo effect
  • a For the degranulation assay, suboptimal Ag-dose was used.

  • b C3a, when added to nonsensitized cells, stimulated only the serosal type RPMC but not the mucosal type RBL-2H3 and BMMC.