Table I.

CTLA-4 dependency of FTY-P enhanced CD4+/CD25+ T regulatory cell activity

FTY-PaCTLA-4bInhibition of [3H]Thymidine Incorporation (%)
21.4 ± 6.1c
+19.9 ± 4.2
+50.6 ± 3.7
++26.2 ± 1.7
  • a FTY-P was used at 1 μM.

  • b Anti-CTLA-4 neutralizing Abs were used at 25 μg/ml.

  • c Mean ± SEM; baseline [3H]thymidine incorporation (100% value) 61 × 10−5 cpm.