Table II.

Change of resolution indices by novel lipid mediators

Ψmax (PMN No. (×106))Tmax (h)T50 (h)Ri (h)
Acute inflammation16.0 ± 0.712.026.4 ± 0.914.4 ± 0.9
+ ATLa 11.7 ± 1.3 a 12.026.0 ± 0.814.0 ± 0.8
+ RvE1 11.6 ± 0.8 b 9.3 ± 0.7 b 21.0 ± 0.6 b 11.7 ± 0.3
+ 10, 17S-docosatriene 9.3 ± 0.5 b 4.0 b 11.3 ± 0.7 b 7.3 ± 0.7 b
  • Data represent mean ± SEM (n = 5–6) and were analyzed by Student’s two-tailed t-test.

  • a p = 0.03,

  • b p < 0.01. All three compounds significantly reduced Ψmax (maximal PMN numbers). In addition, RvE1 shifted Tmax and T50 to earlier time points with no significant change of Ri. Furthermore, 10,17S-docosatriene significantly altered Tmax and T50 as well as shortened Ri.