Table I.

Number of CD4+CD45RBhigh pathogenic T cells (TCRβ+CD45.1+)a

Donor CellsCD4+CD45RBhighCD4+CD45RBhigh + β7+/+ CD25+CD4+CD45RBhigh + β7−/−CD25+
Spleen19 ± 7 × 1057.2 ± 2.7 × 1059.6 ± 5.7 × 105
PLN11 ± 5 × 1057.2 ± 1.1 × 1056.9 ± 1.6 × 105
MLN10 ± 4 × 1059.3 ± 2.1 × 10515 ± 5 × 105
LIEL2 ± 1 × 1050.3 ± 0.1 × 1050.6 ± 0.2 × 105
LLPL23 ± 13 × 1052.9 ± 0.6 × 1055.4 ± 0.8 × 105
  • a CD45.1+RAG2−/− mice were transplanted with CD4+CD45RBhigh T cells alone (left column) or in combination with either 1 × 105 β7+/+CD4+CD25+ Treg (middle column) or β7−/−CD4+CD25+Treg (right column), and upon sacrifice total cell numbers were counted from the indicated organs and multiplied by the percentage of TCRβ+CD45.1+ cells to provide absolute cell numbers of donor CD4+CD45RBhighT cells progeny. Results shown are from one representative experiment (three to four mice per group).