Table I.

Comparison of mature DCs (MHCIIhigh/CD86high) present in the lymph node of septic and sham-treated micea

Operation and Lymph NodeHours Postoperation
61224
CLP mesenteric lymph nodes1.10 ± 0.080.87 ± 0.031.33 ± 0.19
Sham mesenteric lymph nodes1.07 ± 0.281.02 ± 0.051.38 ± 0.09
CLP inguinal lymph nodes0.92 ± 0.070.82 ± 0.141.25 ± 0.27
Sham inguinal lymph nodes0.81 ± 0.060.99 ± 0.071.09 ± 0.11
CLP popliteal lymph nodes1.10 ± 0.111.25 ± 0.161.16 ± 0.08
Sham popliteal lymph nodes0.99 ± 0.131.12 ± 0.181.05 ± 0.05
  • a Numbers represent the ratio of MCHIIhigh/CD86high DCs present, determined by the ratio of MCHIIhigh/CD86high DCs present in the CLP- or sham-treated mice vs those present in the healthy control mice, and the SEM. There was no significant difference in the level of maturity of the DCs present in the lymph nodes during polymicrobial sepsis as compared with sham-operated mice.